Current state and perspectives of dendritic cell vaccination in cancer immunotherapy

被引：13
作者：
Farkas, A.
Conrad, C.
Tonel, G.
Borbenyi, Z.
Kemeny, L.
Dobozy, A.
Nestle, F. O.
机构：
[1] Univ Zurich Hosp, Dept Dermatol, CH-8091 Zurich, Switzerland
[2] Univ Szeged, Dept Dermatol & Allergol, H-6720 Szeged, Hungary
[3] Univ Szeged, Dept Med 2, H-6720 Szeged, Hungary
[4] Univ Szeged, Albert Szent Gyorgyi Med & Pharmaceut Ctr, Ctr Cardiol, Fac Med, H-6720 Szeged, Hungary
来源：
SKIN PHARMACOLOGY AND PHYSIOLOGY | 2006年 / 19卷 / 03期
关键词：
cancer; immunotherapy; dendritic cell vaccination;
D O I：
10.1159/000092592
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Recent progress in the approach towards immunotherapy of cancer consists in molecular definition of tumor antigens, new tools for phenotypical and functional characterization of tumor-specific effector cells and clinical use of novel adjuvants for optimal stimulation of a cancer-specific immune response such as dendritic cells. In spite of these advances and immunological as well as clinical responses in selected patients, mechanisms involved in dendritic-cell-based cancer immunotherapy are still poorly understood. Therefore, a standardized study design and small pilot trials are needed to explore open scientific questions in future clinical trials. This review focuses on the different parameters of dendritic cell biology relevant to cancer immunotherapy and on innovative approaches to hopefully enhance the efficacy of dendritic cell vaccination.
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收藏
页码：124 / 131
页数：8
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