Neuroprotective and antioxidant effects of curcumin in a ketamine-induced model of mania in rats

被引：80

作者：

Gazal, Marta ^{[1
]}

Valente, Matheus R. ^{[1
]}

Acosta, Bruna A. ^{[1
]}

Kaufmann, Fernanda N. ^{[1
]}

Braganhol, Elizandra ^{[2
]}

Lencina, Claiton L. ^{[2
]}

Stefanello, Francieli M. ^{[2
]}

Ghisleni, Gabriele ^{[1
]}

Kaster, Manuella P. ^{[1
]}

机构：

[1] Univ Catolica Pelotas, Programa Posgrad Saude & Comportamento, BR-96015560 Pelotas, RS, Brazil

[2] Univ Fed Pelotas, Ctr Ciencias Quim Farmaceut & Alimentos, Pelotas, RS, Brazil

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2014年 / 724卷

关键词：

Curcumin; Ketamine; Mania; Antioxidant; Neuroprotective; OXIDATIVE STRESS; ANIMAL-MODEL; DIFFERENTIAL SENSITIVITY; SELECTIVE VULNERABILITY; INVOLVEMENT; HIPPOCAMPAL; DISORDER; LITHIUM; NEURONS; EXCITOTOXICITY;

D O I：

10.1016/j.ejphar.2013.12.028

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bipolar disorder (BD) is a chronic and debilitating illness characterized by recurrent manic and depressive episodes. Our research investigates the protective effects of curcumin, the main curcuminoid of the Indian spice turmeric, in a model of mania induced by ketamine administration in rats. Our results indicated that ketamine treatment (25 mg/kg, for 8 days) induced hyperlocomotion in the open-field test and oxidative damage in prefrontal cortex (PFC) and hippocampus (HP), evaluated by increased lipid peroxidation and decreased total thiol content. Moreover, ketamine treatment reduced the activity of the antioxidant enzymes superoxide dismutase and catalase in the FIR Pretreatment of rats with curcumin (20 and 50 mg/kg, for 14 days) or with lithium chloride (45 mg/kg, positive control) prevented behavioral and pro-oxidant effects induced by ketamine. These findings suggest that curcumin might be a good compound for preventive intervention in BD, reducing the episode relapse and the oxidative damage associated with the manic phase of this disorder. (C) 2013 Elsevier B.V. All rights reserved

引用

页码：132 / 139

页数：8

共 52 条

[1]

AEBI H, 1984, METHOD ENZYMOL, V105, P121

[2] Changes in thiol content and expression of glutathione redox system genes in the hippocampus and cerebellum in Alzheimer's disease [J].

Aksenov, MY ;

Markesbery, WR .

NEUROSCIENCE LETTERS, 2001, 302 (2-3) :141-145

[3] Oxidative stress markers in bipolar disorder: A meta-analysis [J].

Andreazza, Ana C. ;

Kauer-Sant'Anna, Marcia ;

Frey, Benicio N. ;

Bond, David J. ;

Kapczinski, Flavio ;

Young, L. Trevor ;

Yatham, Lakshmi N. .

JOURNAL OF AFFECTIVE DISORDERS, 2008, 111 (2-3) :135-144

[4] DNA damage in bipolar disorder [J].

Andreazza, Ana Cristina ;

Frey, Benicio Noronha ;

Erdtmann, Bernardo ;

Salvador, Mirian ;

Rombaldi, Fernanda ;

Santin, Aida ;

Goncalves, Carlos Alberto ;

Kapczinski, Flavio .

PSYCHIATRY RESEARCH, 2007, 153 (01) :27-32

[5] Neuroprotective and anti-ageing effects of curcumin in aged rat brain regions [J].

Bala, Kiran ;

Tripathy, B. C. ;

Sharma, Deepak .

BIOGERONTOLOGY, 2006, 7 (02) :81-89

[6] Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors [J].

Berk, M. ;

Kapczinski, F. ;

Andreazza, A. C. ;

Dean, O. M. ;

Giorlando, F. ;

Maes, M. ;

Yuecel, M. ;

Gama, C. S. ;

Dodd, S. ;

Dean, B. ;

Magalhaes, P. V. S. ;

Amminger, P. ;

McGorry, P. ;

Malhi, G. S. .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2011, 35 (03) :804-817

[7] Adaptogenic potential of curcumin in experimental chronic stress and chronic unpredictable stress-induced memory deficits and alterations in functional homeostasis [J].

Bhatia, Nitish ;

Jaggi, Amteshwar Singh ;

Singh, Nirmal ;

Anand, Preet ;

Dhawan, Ravi .

JOURNAL OF NATURAL MEDICINES, 2011, 65 (3-4) :532-543

[8] Is there a role for curcumin in the treatment of bipolar disorder? [J].

Brietzke, Elisa ;

Mansur, Rodrigo B. ;

Zugman, Andre ;

Carvalho, Andre F. ;

Macedo, Danielle S. ;

Cha, Danielle S. ;

Abilio, Vanessa C. ;

McIntyre, Roger S. .

MEDICAL HYPOTHESES, 2013, 80 (05) :606-612

[9] Folic acid administration prevents ouabain-induced hyperlocomotion and alterations in oxidative stress markers in the rat brain [J].

Brocardo, Patricia S. ;

Budni, Josiane ;

Pavesi, Eloisa ;

Franco, Jeferson L. ;

Uliano-Silva, Marcela ;

Trevisan, Rafael ;

Terenzi, Mariana G. ;

Dafre, Alcir L. ;

Rodrigues, Ana Lucia S. .

BIPOLAR DISORDERS, 2010, 12 (04) :414-424

[10] Diphenyl diselenide ameliorates behavioral and oxidative parameters in an animal model of mania induced by ouabain [J].

Bruening, Cesar Augusto ;

Prigol, Marina ;

Luchese, Cristiane ;

Pinton, Simone ;

Nogueira, Cristina Wayne .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2012, 38 (02) :168-174

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