New dimensions in triazolo[4,3-a]pyrazine derivatives: The land of opportunity in organic and medicinal chemistry

被引：11

作者：

Jethava, Divya J. ^{[1
]}

Borad, Mayuri A. ^{[1
]}

Bhoi, Manoj N. ^{[1
]}

Acharya, Prachi T. ^{[1
]}

Bhaysar, Zeel A. ^{[1
]}

Patel, Hitesh D. ^{[1
]}

机构：

[1] Gujarat Univ, Sch Sci, Dept Chem, Ahmadabad, Gujarat, India

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2020年 / 13卷 / 12期

关键词：

ABT-341; Anti-diabetic activity; Diabetes mellitus; DPP-IV inhibitor; Sitagliptin; Triazolo[4,3-a]pyrazine; PEPTIDASE-IV INHIBITOR; GLUCAGON-LIKE PEPTIDE-1; BIOLOGICAL EVALUATION; ASYMMETRIC-SYNTHESIS; 1,2,4-TRIAZOLO<4,3-A>PYRAZINE DERIVATIVES; PHARMACOLOGICAL EVALUATION; CHIRAL INTERMEDIATE; EFFICIENT SYNTHESIS; RATIONAL DESIGN; DPP-4; INHIBITOR;

D O I：

10.1016/j.arabjc.2020.09.038

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of novel and potent hit molecules have endless demand. The triazolo[4,3-a] pyrazine scaffold is used as an essential building block/scaffold in organic synthesis, which works as a key template for the development of various therapeutic agents. It displays a wide spectrum of potential biological activities that have been progressively studied in recent years on account of their versatile structure and the diverse derivatives that can be synthesized from it to ensure functional motifs. This review article gives an inclusive account of the synthetic utility of triazolo[4,3-a] pyrazine derivatives employed in the design and synthesis of different types of compounds containing various active heterocyclic rings with greater emphasis in recent literature. (C) 2020 Published by Elsevier B.V. on behalf of King Saud University.

引用

页码：8532 / 8591

页数：60

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