A candidate gene association study for nine economically important traits in Italian Holstein cattle

被引:57
|
作者
Fontanesi, L. [1 ,2 ]
Calo, D. G. [3 ]
Galimberti, G. [3 ]
Negrini, R. [4 ,5 ]
Marino, R. [4 ,6 ]
Nardone, A. [7 ]
Ajmone-Marsan, P. [4 ,8 ]
Russo, V. [1 ]
机构
[1] Univ Bologna, Dept Agr & Food Sci, Div Anim Sci, I-40127 Bologna, Italy
[2] Univ Bologna, Ctr Genome Biol, I-40126 Bologna, Italy
[3] Univ Bologna, Dept Stat Sci Paolo Fortunati, I-40126 Bologna, Italy
[4] Univ Cattolica Sacro Cuore, Inst Zootech, I-29122 Piacenza, Italy
[5] Assoc Italiana Allevatori, I-00161 Rome, Italy
[6] Ist Sperimentale Italiano Lazzaro Spallanzani, IDRA LAB, I-26900 Lodi, Italy
[7] Univ Tuscia, Dipartimento Innovaz Sistemi Biol Agroalimentari, I-01100 Viterbo, Italy
[8] Univ Cattolica Sacro Cuore, BioDNA Res Ctr, I-29122 Piacenza, Italy
关键词
dairy cattle; health traits; KIT; milk production; single nucleotide polymorphisms; SOMATIC-CELL SCORE; DAIRY-CATTLE; PROTEIN PERCENTAGE; MILK-PRODUCTION; GENOME SCAN; YIELD; LOCI; POLYMORPHISMS; RECEPTOR; SINGLE;
D O I
10.1111/age.12164
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
We genotyped 58 single nucleotide polymorphisms (SNPs) in 25 candidate genes in about 800 Italian Holstein sires. Fifty-six (minor allele frequency >0.02) were used to evaluate their association with single traits: milk yield (MY), milk fat yield (FY), milk protein yield (PY), milk fat percentage (FP), milk protein percentage (PP), milk somatic cell count (MSCC); and complex indexes: longevity, fertility and productivity-functionality type (PFT), using deregressed proofs, after adjustment for familial relatedness. Thirty-two SNPs were significantly associated (proportion of false positives <0.05) with different traits: 16 with MSCC, 15 with PY, 14 with MY, 12 with PFT, eight with longevity, eight with FY, eight with PP, five with FP and two with fertility. In particular, a SNP in the promoter region of the PRLR gene was associated with eight of nine traits. DGAT1 polymorphisms were highly associated with FP and FY. Casein gene markers were associated with several traits, confirming the role of the casein gene cluster in affecting milk yield, milk quality and health traits. Other SNPs in genes located on chromosome 6 were associated with PY, PP, PFT, MY (PPARGC1A) and MSCC (KIT). This latter association may suggest a biological link between the degree of piebaldism in Holstein and immunological functions affecting somatic cell count and mastitis resistance. Other significant SNPs were in the ACACA, CRH, CXCR1, FASN, GH1, LEP, LGB (also known as PAEP), MFGE8, SRC, TG, THRSP and TPH1 genes. These results provide information that can complement QTL mapping and genome-wide association studies in Holstein.
引用
收藏
页码:576 / 580
页数:5
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