Use of lnCl3 as a cocatalyst and a Cl2Pd(DPEphos)-P(2-Furyl)3 catalyst system for one-pot hydrometalation-cross-coupling and carbometalation-cross-coupling tandem processes

被引：57

作者：

Qian, MX ^{[1
]}

Huang, ZH ^{[1
]}

Negishi, E ^{[1
]}

机构：

[1] Purdue Univ, Hebert C Brown Labs Chem, W Lafayette, IN 47907 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 10期

关键词：

D O I：

10.1021/ol049716f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

One-pot conversion of alkynes to regio- and stereodefined alkenylmetals containing Al and Zr via hydrometalation or carbometalation followed by their Pd-catalyzed cross-coupling with (E)-ICH=CHBr or (E)-ICH=CHCl proceeds cleanly and selectively to give the corresponding 1-halo-1,3-dienes in excellent yields using a catalyst system consisting Of Cl2Pd(DPEphos), DIBAL-H, and TFP (catalyst A) with InCl3 as a cocatalyst.

引用

页码：1531 / 1534

页数：4

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