Ca2+ Channels and Ca2+-Activated K+ Channels in Adult Rat Gonadotrophin-Releasing Hormone Neurones

被引：6

作者：

Kato, M. ^{[1
]}

Tanaka, N. ^{[1
]}

Ishii, H. ^{[1
]}

Yin, C. ^{[1
]}

Sakuma, Y. ^{[1
]}

机构：

[1] Nippon Med Sch, Dept Physiol, Bunkyo Ku, Tokyo 1138602, Japan

来源：

JOURNAL OF NEUROENDOCRINOLOGY | 2009年 / 21卷 / 04期

关键词：

GnRH neurones; Ca channels; SK channels; BK channels; patch clamp; GREEN FLUORESCENT PROTEIN; ESTROGEN-RECEPTOR-BETA; ACTION-POTENTIAL INITIATION; ELECTROPHYSIOLOGICAL PROPERTIES; POTASSIUM CHANNELS; CALCIUM CURRENTS; REPOLARIZATION; AFTERHYPERPOLARIZATION; IMMUNOREACTIVITY; EXPRESSION;

D O I：

10.1111/j.1365-2826.2009.01849.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gonadotrophin-releasing hormone (GnRH) neurones represent the final output neurones in the neuroendocrine system for the control of reproduction. To understand the reproductive neuroendocrine system, an investigation of the intrinsic and extrinsic properties of GnRH neurones is essential. In this review, we focus on the intrinsic properties and summarise our recent findings of ion channels expressed in rat GnRH neurones. Rat GnRH neurones express all four types of high voltage-activated Ca(2+)channel (L, N, P/Q, R) and the low voltage-activated Ca2+ channel (T). GnRH neurones also express two types of Ca2+-activated K+ [K(Ca)] channel: the small conductance Ca2+-activated K+ (SK) channel and the large conductance Ca2+- and voltage-activated K+ (BK) channel. The activities of these Ca2+ and K(Ca) channels regulate cell excitability and cellular calcium homeostasis.

引用

页码：312 / 315

页数：4

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