Oxygenated cembranoids of the decaryiol type from the Indonesian soft coral Lobophytum sp.

被引：29
作者：
Fattorusso, Ernesto [1 ]
Romano, Adriana [1 ]
Taglialatela-Scafati, Orazio [1 ]
Irace, Carlo [2 ]
Maffettone, Carmen [2 ]
Bavestrello, Giorgio [3 ]
Cerrano, Carlo [4 ]
机构：
[1] Univ Naples Federico 2, Dipartimento Chim Sosranze Nat, I-80131 Naples, Italy
[2] Univ Naples Federico 2, Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy
[3] Univ Politecn Marche, Dipartimento Sci Mare, I-60131 Ancona, Italy
[4] Univ Genoa, Dipartimento Terr Risorse, I-16132 Genoa, Italy
来源：
TETRAHEDRON | 2009年 / 65卷 / 15期
关键词：
Soft corals; Cembranoids; Decaryiol; Growth inhibition; SPONGE PLAKORTIS-SIMPLEX; DITERPENE; OCTOCORALLIA; ALCYONACEA; FAMILY; CELLS;
D O I：
10.1016/j.tet.2009.02.008
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Three novel cembrane diterpenoids, decaryiols B-D (5-7). characterized by a bicyclic skeleton of the decaryiol-type, have been isolated from the Indonesian soft coral Lobophytum sp., along with three known cembranoids. The stereostructures of these metabolites have been established through extensive NMR spectroscopic analysis, application of the modified Mosher method, and chemical conversion. cembranoids obtained from Lobophytum sp. (2-7) and six semisynthetic derivatives (9-14) prepared from decaryiol were tested for cell growth inhibitory activity against three different cell lines. O-Methyl decaryiol (10) exhibited a significant and selective activity against glioma cell lines. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2898 / 2904
页数：7
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