Microwave-Assisted Synthesis of Heterocycles from Aryldiazoacetates**

被引：8

作者：

Kristoffersen, Tone ^{[1
]}

Elumalai, Vijayaragavan ^{[1
]}

Starck, Eliot ^{[1
]}

Cousin, Etienne ^{[1
]}

Wagner, Lucille J. ^{[1
]}

Hansen, Stephanie R. ^{[1
]}

Hansen, Jorn H. ^{[1
]}

机构：

[1] UiT Arctic Univ Norway, Dept Chem, Chem Synth & Anal Grp, Hansine Hansens Veg 54, N-9037 Tromso, Norway

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 45期

关键词：

Microwave; Diazoacetates; N– H insertion; Dihydroquinoxalinones; Quinoxalines; CARBENE INSERTION; ORGANIC-SYNTHESIS; QUINOXALINES;

D O I：

10.1002/ejoc.202001155

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we describe a rapid microwave-assisted, metal-free synthesis of substituted quinoxalinones and quinoxalines using the carbene-mediated reaction between aryldiazo esters and 1,2-diamines. The reaction can encompass a range of substituents and structural variations to afford quinoxalin-2-ones in 14-80 % yield and corresponding quinoxalines in good to excellent yields upon oxidation (67-96 %). The approach can be employed to generate symmetrical and unsymmetrical 2,3-diarylquinoxalines, bis-quinoxalines as well as novel quinoxaline-substituted diazo esters and should be a valuable addition to the heterocycle synthesis toolbox.

引用

页码：7069 / 7078

页数：10

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