Total Synthesis of Natural Dihydropyranones: A Contribution to the Structural Elucidation of Natural Products. Coibacins A and B, Cryptomoscatones D1, D2 and E3

被引：2

作者：

Pilli, Ronaldo Aloise ^{[1
]}

Toneto Novaes, Luiz Fernando ^{[1
]}

Teixeira Carneiro, Vania Maria ^{[1
]}

Drekener, Roberta Lopes ^{[1
]}

Avila, Carolina Martins ^{[1
]}

机构：

[1] Univ Estadual Campinas, UNICAMP, Inst Chem, Campinas, SP, Brazil

来源：

CURRENT ORGANIC SYNTHESIS | 2015年 / 12卷 / 05期

基金：

巴西圣保罗研究基金会;

关键词：

Polyketides; Total Synthesis; Structural Elucidation; Coibacin; Cryptomoscatone; STEREOSELECTIVE-SYNTHESIS; ABSOLUTE-CONFIGURATION; IN-VITRO; KETONES; DESIGN; DERIVATIVES; ALLYLATION; ASSIGNMENT; ESTERS; NMR;

D O I：

10.2174/157017941205150821121851

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cryptomoscatones D1 and D2, dihydropyranones isolated from C. mandiocanna, had their stereochemistry solved after total syntheses and comparison of spectroscopic data of natural and synthetic samples. Natural dihydropyranones coibacins A and B, metabolites isolated from marine cyanobacterium cf. Oscillatoria sp, which display antileishmanial activity and anti-inflammatory properties, were synthesized and had their absolute configuration determined. Our efforts towards the synthesis of cryptomoscatone E3, natural dihydropyranone with unknown absolute configuration, are also discussed.

引用

页码：523 / 529

页数：7

共 11 条

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