Association of glycemic status and interferon-γ production with leukocytes and platelet indices alterations in type2 diabetes

Aims: The present study aimed to evaluate the correlation between glycemic status and the inflammation biomarkers; leukocytes, platelets indices and interferon gamma (IFN-gamma) production in type 2 diabetes mellitus (T2DM) patients regarding diabetic complications. Methods: Study was conducted on 158 patients allocated as normal healthy subjects (50) and 108 patients diagnosed as T2DM. The diabetic patients were subdivided into six groups according to metformin administration as mono-or dual therapies. Results: The current results exhibited a significant elevation in systolic blood pressure, total and LDL-cholesterol levels and IFN-gamma as well as a noticeable decrease in HDL-cholesterol and anti-atherogenic factor values compared to the healthy patients. Leukocytes and neutrophils count, main platelets volume (MPV) and platelet distribution width (PDW) values revealed noticeable elevations in most treated T2DM groups, while a marked depletion was recorded in platelets count compared to healthy subjects. Glycemic control, most treated diabetic patients with metformin mono- and dual therapies showed an ameliorative effect in HbA1c, IFN-gamma, MPV, and PDW values compared to recent diabetic ones. Conclusion: Diabetes was correlated significantly with dyslipidemia and atherogenic risk in parallel with an increase in IFN-gamma production and hematological inflammatory biomarkers; leukocytes, neutrophil/lymphocyte and platelet/lymphocyte ratios, MPV and PDW values. The amelioration in inflammatory biomarkers was associated with improvement in glycemic control. (C) 2019 Published by Elsevier Ltd on behalf of Diabetes India.