Regioselective synthesis of 3-aryl-5-(1H-indole-3-carbonyl)-4-hydroxyfuroic acids as potential insulin receptor activators

被引：7

作者：

Chou, Shan-Yen ^{[1
]}

Chen, Shieh-Shung Tom ^{[1
]}

Chen, Ching-Hui ^{[1
]}

Chang, Lien-Shange ^{[1
]}

机构：

[1] Dev Ctr Biotechnol, Taipei 221, Taiwan

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 43期

关键词：

D O I：

10.1016/j.tetlet.2006.08.076

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Methoxy-4-aryl-furan-2,5-dicarboxylic acid (8) is selectively converted into its C-5 methylester (6) by treatment with methyl chloroformate followed by decarboxylation in one flask. Acylation of the resulting half ester with a 7-substituted indole was performed under mild conditions to afford 3-aryl-5-(1H-indole-3-carbonyl)-4-methoxy-2-furoic acid (11). The synthetic utility of the resulting furoic acids as a skeleton in the synthesis of potential insulin receptor activators is established. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：7579 / 7582

页数：4

共 6 条

[1]

CHEN SS, 2003, Patent No. 6596760

[2] CARBOXY DERIVATIVES OF BENZYLPENICILLIN [J].