Marine microbial L-asparaginase: Biochemistry, molecular approaches and applications in tumor therapy and in food industry

被引:94
作者
Qeshmi, Fatemeh Izadpanah [1 ]
Homaei, Ahmad [2 ]
Fernandes, Pedro [3 ,4 ,5 ]
Javadpour, Sedigheh [6 ]
机构
[1] Univ Hormozgan, Dept Marine Biol, Fac Sci, Bandar Abbas, Iran
[2] Univ Hormozgan, Dept Biol, Fac Sci, POB 3995, Bandar Abbas, Iran
[3] Univ Lisbon, Inst Super Tecn, Dept Bioengn, Av Rovisco Pais, P-1049001 Lisbon, Portugal
[4] Univ Lisbon, Inst Super Tecn, IBB, Av Rovisco Pais, P-1049001 Lisbon, Portugal
[5] Univ Lusofona Humanidades & Tecnol, Fac Engn, Av Campo Grande 376, P-1749024 Lisbon, Portugal
[6] Hormozgan Univ Med Sci, Hormozgan Hlth Inst, Mol Med Res Ctr, Bandar Abbas, Iran
关键词
L-asparaginase; Marine bacteria; Biotechnological application; ACUTE LYMPHOBLASTIC-LEUKEMIA; CAROTOVORA L-ASPARAGINASE; ESCHERICHIA-COLI; MYCOBACTERIUM-TUBERCULOSIS; SUBSTRATE-SPECIFICITY; ACRYLAMIDE REDUCTION; ERWINIA-ASPARAGINASE; PARTIAL-PURIFICATION; BACILLUS-SUBTILIS; POTATO-CHIPS;
D O I
10.1016/j.micres.2018.01.011
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The marine environment is a rich source of biological and chemical diversity. It covers more than 70% of the Earth's surface and features a wide diversity of habitats, often displaying extreme conditions, where marine organisms thrive, offering a vast pool for microorganisms and enzymes. Given the dissimilarity between marine and terrestrial habitats, enzymes and microorganisms, either novel or with different and appealing features as compared to terrestrial counterparts, may be identified and isolated. L-asparaginase (E.C. 3.5.1.1), is among the relevant enzymes that can be obtained from marine sources. This amidohydrolase acts on L-asparagine and produce L-aspartate and ammonia, accordingly it has an acknowledged chemotherapeutic application, namely in acute lymphoblastic leukemia. Moreover, L-asparaginase is also of interest in the food industry as it prevents acrylamide formation. Terrestrial organisms have been largely tapped for L-asparaginases, but most failed to comply with criteria for practical applications, whereas marine sources have only been marginally screened. This work provides an overview on the relevant features of this enzyme and the framework for its application, with a clear emphasis on the use of L-asparaginase from marine sources. The review envisages to highlight the unique properties of marine L-asparaginases that could make them good candidates for medical applications and industries, especially in food safety.
引用
收藏
页码:99 / 112
页数:14
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