follicular lymphoma;
bone marrow trephine biopsy;
flow cytometry;
bone marrow involvement;
D O I:
10.1080/10428190600709127
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Bone marrow (BM) examination is a routine staging procedure in follicular lymphoma (FL). Commonly, both BM histology as well as flow cytometry (FCM) of BM aspirates are performed. In order to compare the diagnostic value of these two techniques, we retrospectively evaluated trephine BM biopsies and listmode data of patients with a confirmed diagnosis of FL, obtained in parallel during a 5-year period. One hundred and thirty nine specimens from 91 patients with FL were eligible for analysis. After joint review, nine cases (6.5%) were reclassified, either in histology (six cases) or FCM (three cases). Seventy nine specimens (57%) showed no infiltration with both methods. Sixty specimens (43%) were scored positive for BM involvement by any of the two techniques. Concordant positive results were obtained in 41 cases (68% of positive BM). False negative results were obtained by FCM in 14 cases (23% of positive BM) and by histology in five cases (8%). Discrepant results between BM histology and FCM are frequent in patients with FL, most likely due to the predominantly paratrabecular infiltration and fibrosis typical for FL. Due to the lower false negative rate, trephine BM biopsy remains crucial for the detection of BM involvement in FL.
机构:
Hosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, SpainHosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, Spain
Cortes-Romera, M.
Mercadal-Vilchez, S.
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机构:
Hosp Duran & Reynals, IDIBELL, Dept Hematol, ICO, Lhospitalet De Llobregat, Barcelona, SpainHosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, Spain
Mercadal-Vilchez, S.
Llinares-Tello, E.
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Hosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, SpainHosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, Spain
Llinares-Tello, E.
Carro, I.
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机构:
Hosp Duran & Reynals, IDIBELL, Dept Hematol, ICO, Lhospitalet De Llobregat, Barcelona, SpainHosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, Spain
Carro, I.
Sabate-Llobera, A.
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Hosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, SpainHosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, Spain
Sabate-Llobera, A.
Vercher-Conejero, J.
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Hosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, SpainHosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, Spain
Vercher-Conejero, J.
Gracia-Sanchez, L.
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Hosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, SpainHosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, Spain
Gracia-Sanchez, L.
Climent-Esteller, F.
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Hosp Univ Bellvitge, IDIBELL, Dept Pathol, Lhospitalet De Llobregat, Barcelona, SpainHosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, Spain
Climent-Esteller, F.
Romero-Zayas, I.
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Hosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, SpainHosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, Spain
Romero-Zayas, I.
Gonzalez-Barca, E.
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机构:
Hosp Duran & Reynals, IDIBELL, Dept Hematol, ICO, Lhospitalet De Llobregat, Barcelona, SpainHosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, Spain
Gonzalez-Barca, E.
Mestres-Martin, J.
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Hosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, SpainHosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, Spain
Mestres-Martin, J.
Gamez-Cenzano, C.
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Hosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, SpainHosp Univ Bellvitge, IDIBELL, Pet Unit Nucl Med, IDI, Lhospitalet De Llobregat, Barcelona, Spain
机构:
Kings Coll London, St Thomas Hosp, Ctr Haematooncol, London SE1 7EH, EnglandKings Coll London, St Thomas Hosp, Ctr Haematooncol, London SE1 7EH, England
El-Najjar, Inas
Montoto, Silvia
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机构:
Kings Coll London, St Thomas Hosp, Ctr Haematooncol, London SE1 7EH, EnglandKings Coll London, St Thomas Hosp, Ctr Haematooncol, London SE1 7EH, England
Montoto, Silvia
McDowell, Amy
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机构:
Kings Coll London, St Thomas Hosp, Dept Nucl Med, Ctr Mol Oncol,Barts Canc Inst, London SE1 7EH, EnglandKings Coll London, St Thomas Hosp, Ctr Haematooncol, London SE1 7EH, England
McDowell, Amy
Matthews, Janet
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机构:
Kings Coll London, St Thomas Hosp, Ctr Haematooncol, London SE1 7EH, EnglandKings Coll London, St Thomas Hosp, Ctr Haematooncol, London SE1 7EH, England
Matthews, Janet
Gribben, John
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机构:
Kings Coll London, St Thomas Hosp, Ctr Haematooncol, London SE1 7EH, EnglandKings Coll London, St Thomas Hosp, Ctr Haematooncol, London SE1 7EH, England
Gribben, John
Szyszko, Teresa A.
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机构:
Kings Coll London, St Thomas Hosp, Dept Nucl Med, Ctr Mol Oncol,Barts Canc Inst, London SE1 7EH, England
Kings Coll London, Div Imaging Sci & Biomed Engn, Clin PET Ctr, St Thomas Hosp, London SE1 7EH, EnglandKings Coll London, St Thomas Hosp, Ctr Haematooncol, London SE1 7EH, England