Oxidative stress response to menadione and cumene hydroperoxide in the opportunistic fungal pathogen Candida glabrata

被引：32
|
作者：
Cuellar-Cruz, Mayra [1 ,2 ]
Castano, Irene [1 ]
Arroyo-Helguera, Omar [1 ]
De Las Penas, Alejandro [1 ]
机构：
[1] Inst Potosino Invest Cient & Tecnol, Div Mol Biol, San Luis Potosi 78216, SLP, Mexico
[2] Univ Autonoma Estado Hidalgo, Inst Ciencias Basicas & Ingn, Area Acad Quim, Pachuca 42060, HGO, Mexico
来源：
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2009年 / 104卷 / 04期
关键词：
Candida glabrata; menadione; cumene; CTA1; Candida albicans; Saccharomyces cerevisiae; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTIONAL REGULATION; YEAST; GENE; ALBICANS; ACTIVATION; EXPRESSION; PROTECTION; RESISTANCE; PEROXIDE;
D O I：
10.1590/S0074-02762009000400020
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Candida glabrata is an opportunistic fungal pathogen that can cause severe invasive infections and can evade phagocytic cell clearance. We are interested in understanding the virulence of this fungal pathogen, in particular its oxidative stress response. Here we investigated C. glabrata, Saccharomyces cerevisiae and Candida albicans responses to two different oxidants: menadione and cumene hydroperoxide (CHP). In log-phase, in the presence of menadione, C. glabrata requires Cta1p (catalase), while in a stationary phase (SP), Cta1p is dispensable. In addition, C. glabrata is less resistant to menadione than C. albicans in SP. The S. cerevisiae laboratory reference strain is less resistant to menadione than C. glabrata and C. albicans; however S. cerevisiae clinical isolates (CIs) are more resistant than the lab reference strain. Furthermore, S. cerevisiae CIs showed an increased catalase activity. Interestingly, in SP C. glabrata and S. cerevisiae are more resistant to CHP than C. albicans and Cta1p plays no apparent role in detoxifying this oxidant.
引用
收藏
页码：649 / 654
页数：6
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