A genome-based strategy uncovers frequent BRAF mutations in melanoma

被引：115

作者：

Pollock, PM ^{[1
]}

Meltzer, PS ^{[1
]}

机构：

[1] NHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA

来源：

CANCER CELL | 2002年 / 2卷 / 01期

关键词：

D O I：

10.1016/S1535-6108(02)00089-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using a genome-scanning approach to search for oncogenes, a recent report identifies somatic mutations in the signaling gene BRAF that are particularly prevalent in melanoma.

引用

页码：5 / 7

页数：3

共 12 条

[1] Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity [J].

Ali, IU ;

Schriml, LM ;

Dean, M .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (22) :1922-1932

[2] Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes [J].

Buscà, R ;

Abbe, P ;

Mantoux, F ;

Aberdam, E ;

Peyssonnaux, C ;

Eychène, A ;

Ortonne, JP ;

Ballotti, R .

EMBO JOURNAL, 2000, 19 (12) :2900-2910

[3] Essential role for oncogenic Ras in tumour maintenance [J].

Chin, L ;

Tam, A ;

Pomerantz, J ;

Wong, M ;

Holash, J ;

Bardeesy, N ;

Shen, Q ;

O'Hagan, R ;

Pantginis, J ;

Zhou, H ;

Horner, JW ;

Cordon-Cardo, C ;

Yancopoulos, GD ;

DePinho, RA .

NATURE, 1999, 400 (6743) :468-472

[4] Mutations of the BRAF gene in human cancer [J].

Davies, H ;

Bignell, GR ;

Cox, C ;

Stephens, P ;

Edkins, S ;

Clegg, S ;

Teague, J ;

Woffendin, H ;

Garnett, MJ ;

Bottomley, W ;

Davis, N ;

Dicks, N ;

Ewing, R ;

Floyd, Y ;

Gray, K ;

Hall, S ;

Hawes, R ;

Hughes, J ;

Kosmidou, V ;

Menzies, A ;

Mould, C ;

Parker, A ;

Stevens, C ;

Watt, S ;

Hooper, S ;

Wilson, R ;

Jayatilake, H ;

Gusterson, BA ;

Cooper, C ;

Shipley, J ;

Hargrave, D ;

Pritchard-Jones, K ;

Maitland, N ;

Chenevix-Trench, G ;

Riggins, GJ ;

Bigner, DD ;

Palmieri, G ;

Cossu, A ;

Flanagan, A ;

Nicholson, A ;

Ho, JWC ;

Leung, SY ;

Yuen, ST ;

Weber, BL ;

Siegler, HF ;

Darrow, TL ;

Paterson, H ;

Marais, R ;

Marshall, CJ ;

Wooster, R .

NATURE, 2002, 417 (6892) :949-954

[5] Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma [J].

Demunter, A ;

Stas, M ;

Degreef, H ;

De Wolf-Peeters, C ;

van den Oord, JJ .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 117 (06) :1483-1489

[6]

GREENBLATT MS, 1994, CANCER RES, V54, P4855

[7] Modelling the molecular circuitry of cancer [J].

Hahn, WC ;

Weinberg, RA .

NATURE REVIEWS CANCER, 2002, 2 (05) :331-341

[8]

Herlyn M, 1996, AM J PATHOL, V149, P739

[9] Signalling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes [J].

Imokawa, G ;

Yada, Y ;

Kimura, M .

BIOCHEMICAL JOURNAL, 1996, 314 :305-312

[10] Neonatal sunburn and melanoma in mice - Severe sunburn in newborn, but not adult, mice is linked with melanoma in later life. [J].

Noonan, FP ;

Recio, JA ;

Takayama, H ;

Duray, P ;

Anver, MR ;

Rush, WL ;

De Fabo, EC ;

Merlino, G .

NATURE, 2001, 413 (6853) :271-272

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