Anti-Obesity Effect of Carotenoids: Direct Impact on Adipose Tissue and Adipose Tissue-Driven Indirect Effects

被引：105
作者：
Mounien, Lourdes [1 ]
Tourniaire, Franck [1 ,2 ]
Landrier, Jean-Francois [1 ,2 ]
机构：
[1] Aix Marseille Univ, INSERM, INRA, C2VN, F-13385 Marseille, France
[2] CriBioM, Criblage Biol Marseille, Fac Med Timone, F-13256 Marseille, France
来源：
NUTRIENTS | 2019年 / 11卷 / 07期
关键词：
adipocytes; adipose tissue; brain; carotenoids; obesity; UNION-OF-PHARMACOLOGY; HIGH-FAT DIET; NF-KAPPA-B; RETINOIC ACID; BETA-CAROTENE; ACTIVATED RECEPTOR; GENE-EXPRESSION; VITAMIN-A; ADIPOCYTE DIFFERENTIATION; CHEMOKINE EXPRESSION;
D O I：
10.3390/nu11071562
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
This review summarizes current knowledge on the biological relevance of carotenoids and some of their metabolites in obesity management. The relationship between carotenoids and obesity is considered in clinical studies and in preclinical studies. Adipose tissue is a key organ in obesity etiology and the main storage site for carotenoids. We thus first describe carotenoid metabolism in adipocyte and adipose tissue and the effects of carotenoids on biological processes in adipose tissue that may be linked to obesity management in in vitro and preclinical studies. It is also now well established that the brain is strongly involved in obesity processes. A section is accordingly devoted to the potential effect of carotenoids on obesity via their direct and/or adipose tissue-driven indirect biological effects on the brain.
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页数：14
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