Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity

被引：750
作者：
Bogdan, C
Röllinghoff, M
Diefenbach, A
机构：
[1] Univ Erlangen Nurnberg, Inst Clin Microbiol Immunol & Hyg, D-91054 Erlangen, Germany
[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 01期
关键词：
D O I：
10.1016/S0952-7915(99)00052-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Nitric oxide, nitric oxide derivatives and reactive oxygen intermediates are toxic molecules of the immune system which contribute to the control of microbia[ pathogens and tumors. There is recent evidence for additional functions of these oxygen metabolites in innate and adaptive immunity; these functions include the modulation of the cytokine response of lymphocytes and the regulation of immune cell apoptosis, as well as immunodeviating effects. Components of several signal transduction pathways have been identified as intracellular targets for reactive nitrogen and oxygen intermediates.
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页码：64 / 76
页数：13
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