Facile preparation of 3,5-disubstituted-4-aminothiophene-2-carbaldehyde from a novel unexpected domino reaction of vinyl azides and 1,4-dithiane-2,5-diol

被引：22

作者：

Chen, Binhui ^{[1
]}

Ni, Hangcheng ^{[1
]}

Guo, Xiao ^{[1
]}

Zhang, Guolin ^{[1
]}

Yu, Yongping ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Zhejiang, Peoples R China

来源：

RSC ADVANCES | 2014年 / 4卷 / 84期

基金：

美国国家科学基金会;

关键词：

ONE-POT SYNTHESIS; GEWALD SYNTHESIS; 2-AMINOTHIOPHENES; DERIVATIVES; INHIBITORS; THIOPHENES;

D O I：

10.1039/c4ra08649j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and direct synthesis of 3,5-disubstituted-4-aminothiophene-2-carbaldehyde from vinyl azides and 1,4-dithiane-2,5-diol was developed. An attractive feature of this protocol is that the desired products are generated in a highly efficient and eco-friendly manner. A plausible mechanism has been proposed.

引用

页码：44462 / 44465

页数：4

共 43 条

[1] Cyclopropyl building blocks in organic synthesis, part 84. A new and productive route to 1-heteroarylcyclopropanols [J].