Transdermal delivery of salbutamol sulphate: Formulation and evaluation

被引：2

作者：

El-Gendy, Nashwa A. ^{[1
]}

Sabry, Nirmeen A. ^{[2
]}

El-Attar, Mai ^{[3
]}

Omar, Emad ^{[4
]}

Mahmoud, Manal ^{[5
]}

机构：

[1] Beni Suef Univ, Fac Pharm, Dept Pharmaceut, Bani Suwayf, Egypt

[2] Cairo Univ, Fac Pharm, Dept Clin Pharm, Cairo, Egypt

[3] Ain Shams Univ, Chest Dept, Fac Med, Cairo, Egypt

[4] Cairo Univ, Intens Care Unit, Fac Med, Cairo, Egypt

[5] Ain Shams Univ, Dept Internal Med, Fac Med, Cairo, Egypt

来源：

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | 2009年 / 14卷 / 02期

关键词：

Salbutamol sulphate; transdermal; patches; POLYVINYL-ALCOHOL FILMS; IN-VITRO; PENETRATION ENHANCERS; HUMAN-SKIN; OLEIC-ACID; PLASTICIZERS; PERMEATION; DESIGN; PATCH; DICLOFENAC;

D O I：

10.1080/10837450802572383

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Salbutamol patches were prepared and evaluated. The effect of different Eudragits and various plasticizers on the properties of the patches were studied. Patches were prepared by casting method employing different plasticizers. These patches were evaluated for weight, thickness uniformity, swelling index, tensile strength, elongation percent and moisture absorption capacity. Release was studied. Tensile strength of the patches using Eudragit RS 100 as well as RS 100 + L100 and triacetin was the lowest. Formulae containing 10% oleic acid and 5% dimethyl formamide, respectively, showed the highest permeability. These two formulae were studied clinically, the first formula only showed a significant improvement.

引用

页码：216 / 225

页数：10

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