Accumulation of immunoglobulin G against Dermatophagoides farinae tropomyosin in dorsal root ganglia of NC/Nga mice with atopic dermatitis-like symptoms

被引：1

作者：

Otsu, Ayaka ^{[1
,2
]}

Kawasaki, Hiroaki ^{[2
]}

Tominaga, Mitsutoshi ^{[2
]}

Shigenaga, Ayako ^{[3
]}

Matsuda, Hironori ^{[2
]}

Takahashi, Nobuaki ^{[2
]}

Nakajima, Tadaaki ^{[1
]}

Naito, Hisashi ^{[3
]}

Baba, Takeshi ^{[4
]}

Ogawa, Hideoki ^{[2
]}

Tomooka, Yasuhiro ^{[1
]}

Yamakura, Fumiyuki ^{[5
]}

Takamori, Kenji ^{[2
,6
]}

机构：

[1] Tokyo Univ Sci, Fac Ind Sci & Technol, Dept Biol Sci & Technol, Katsushika ku, 6-3-1 Niijuku, Tokyo 1258585, Japan

[2] Juntendo Univ, Grad Sch Med, Inst Environm & Gender Specif Med, 2-1-1 Tomioka, Chiba 2790021, Japan

[3] Juntendo Univ, Inst Hlth & Sports Sci & Med, 1-1 Hirakagakuendai, Chiba 2701695, Japan

[4] Juntendo Univ, Sch Med, 1-1 Hirakagakuendai, Chiba 2701695, Japan

[5] Juntendo Univ, Fac Int Liberal Arts, Bunkyo Ku, 2-1-1,Hongo, Tokyo 1138421, Japan

[6] Juntendo Univ, Urayasu Hosp, Dept Dermatol, 2-1-1 Tomioka, Chiba 2790021, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2017年 / 485卷 / 04期

基金：

日本学术振兴会;

关键词：

Atopic dermatitis; Dorsal root ganglia; IgG; Itch; Tropomyosin; SATELLITE GLIAL-CELLS; ITCH; PAIN; MECHANISMS; PRURITUS; ALPHA;

D O I：

10.1016/j.bbrc.2017.02.109

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Atopic dermatitis (AD), a chronic inflammatory skin disease, manifests as intractable itch, but its underlying mechanisms are poorly understood. This study assessed the relationship between immunoglobulin G (IgG) and dorsal root ganglia (DRG) in NC/Nga mice, a model of AD that manifests AD-like symptoms including itch. Immunohistochemical analysis showed large amounts of IgG in DRG extracts of NC/Nga mice with AD-like dermatitis, with a large fraction of the IgG distributed in satellite glial cells of the DRG. Proteomic analysis showed that this IgG was reactive against tropomyosin of Dermatophagoides farinae. These findings indicate that the accumulation of anti-tropomyosin IgG in DRG of atopic NC/Nga mice may be associated with the pathogenesis of AD-like symptoms, including itch. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：707 / 712

页数：6

共 25 条

[1] Direct action of immunoglobulin G on primary sensory neurons through Fc gamma receptor I
Andoh, T
Kuraishi, Y
[J]. FASEB JOURNAL, 2004, 18 (01) : 182 - 184
[2] Importance of epidermal keratinocytes in itch
Andoh, Tsugunobu
[J]. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2006, 126 (06): : 403 - 408
[3] Der p 11 Is a Major Allergen for House Dust Mite-Allergic Patients Suffering from Atopic Dermatitis
Banerjee, Srinita
Resch, Yvonne
Chen, Kuan-Wei
Swoboda, Ines
Focke-Tejkl, Margit
Blatt, Katharina
Novak, Natalija
Wickman, Magnus
van Hage, Marianne
Ferrara, Rosetta
Mari, Adriano
Purohit, Ashok
Pauli, Gabrielle
Sibanda, Elopy N.
Ndlovu, Portia
Thomas, Wayne R.
Krzyzanek, Vladislav
Tacke, Sebastian
Malkus, Ursula
Valent, Peter
Valenta, Rudolf
Vrtala, Susanne
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2015, 135 (01) : 102 - 109
[4] Cellular and Molecular Mechanisms of Pain
Basbaum, Allan I.
Bautista, Diana M.
Scherrer, Gregory
Julius, David
[J]. CELL, 2009, 139 (02) : 267 - 284
[5] Why we scratch an itch: the molecules, cells and circuits of itch
Bautista, Diana M.
Wilson, Sarah R.
Hoon, Mark A.
[J]. NATURE NEUROSCIENCE, 2014, 17 (02) : 175 - 182
[6] Feeling good: on the role of C fiber mediated touch in interoception
Bjornsdotter, M.
Morrison, I.
Olausson, H.
[J]. EXPERIMENTAL BRAIN RESEARCH, 2010, 207 (3-4) : 149 - 155
[7] SYSTEMIC INFLAMMATION ALTERS SATELLITE GLIAL CELL FUNCTION AND STRUCTURE. A POSSIBLE CONTRIBUTION TO PAIN
Blum, E.
Procacci, P.
Conte, V.
Hanani, M.
[J]. NEUROSCIENCE, 2014, 274 : 209 - 217
[8] Component-resolved diagnosis with commercially available D. pteronyssinus Der p 1, Der p 2 and Der p 10: relevant markers for house dust mite allergy
Bronnert, M.
Mancini, J.
Birnbaum, J.
Agabriel, C.
Liabeuf, V.
Porri, F.
Cleach, I.
Fabre, A.
Deneux, I.
Grandne, V.
Grob, J. -J.
Berbis, P.
Charpin, D.
Bongrand, P.
Vitte, J.
[J]. CLINICAL AND EXPERIMENTAL ALLERGY, 2012, 42 (09) : 1406 - 1415
[9] Satellite glial cells in sensory ganglia: Their possible contribution to inflammatory pain
Dublin, Pavel
Hanani, Menachem
[J]. BRAIN BEHAVIOR AND IMMUNITY, 2007, 21 (05) : 592 - 598
[10] Painful stimuli evoke itch in patients with chronic pruritus - Central sensitization for itch
Ikoma, A
Fartasch, M
Heyer, G
Miyachi, Y
Handwerker, H
Schmelz, M
[J]. NEUROLOGY, 2004, 62 (02) : 212 - 217

← 1 2 3 →