Anti-tumor promoters phenolics and triterpenoid from Hippophae rhamnoides

被引：46

作者：

Yasukawa, Ken ^{[1
]}

Kitanaka, Susumu ^{[1
]}

Kawata, Kenji ^{[1
]}

Goto, Kumiko ^{[1
]}

机构：

[1] Nihon Univ, Coll Pharm, Chiba 2748555, Japan

来源：

FITOTERAPIA | 2009年 / 80卷 / 03期

关键词：

Cancer chemoprevention; Two-stage carcinogenesis; Hippophae rhamnoides; URSOLIC ACID; TUMOR PROMOTION; 2-STAGE CARCINOGENESIS; NITRIC-OXIDE; L; 12-O-TETRADECANOYLPHORBOL-13-ACETATE; TRANSCRIPTION; INHIBITION; COMPONENT; RICE;

D O I：

10.1016/j.fitote.2009.01.006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A 70% ethanol extract of the branches of Hippophae rhamnoides exhibited remarkable antitumor activity in an in vivo two-stage carcinogenesis test in mice using 7,12dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. From the active fraction of the 70% ethanol extract, three phenolic compounds, (+)-catechin (1), (+)-gallocatechin (2), and (-)-epigallocatechin (3) and a tritepenoid, ursolic acid (4) were isolated and identified. These compounds were evaluated for their inhibitory effects on TPA-induced inflammation (1 mu g/ear) in mice. Within the tested compounds, 3 and 4 showed marked anti-inflammatory effects, with a 50% inhibitory dose of 1.7 and 0.2 mu mol/ear. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：164 / 167

页数：4

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