Saffron: The Golden Spice with Therapeutic Properties on Digestive Diseases

被引：126

作者：

Ashktorab, Hassan ^{[1
,2
]}

Soleimani, Akbar ^{[1
,2
]}

Singh, Gulshan ^{[3
]}

Amin, Amr ^{[4
]}

Tabtabaei, Solmaz ^{[5
]}

Latella, Giovanni ^{[6
]}

Stein, Ulrike ^{[7
,8
,9
]}

Akhondzadeh, Shahin ^{[10
]}

Solanki, Naimesh ^{[11
]}

Gondre-Lewis, Marjorie C. ^{[11
]}

Habtezion, Aida ^{[3
]}

Brim, Hassan ^{[1
,2
]}

机构：

[1] Howard Univ, Coll Med, Dept Med, Dept Pathol, Washington, DC 20059 USA

[2] Howard Univ, Coll Med, Ctr Canc, Washington, DC 20059 USA

[3] Stanford Univ, Div Gastroenterol & Hepatol, Sch Med, Stanford, CA 94305 USA

[4] UAE Univ, Dept Biol, Al Ain 15551, U Arab Emirates

[5] Howard Univ, Dept Chem Engn, Washington, DC 20059 USA

[6] Univ Aquila, Gastroenterol Hepatol & Nutr Div, Dept Life Hlth & Environm Sci, I-67100 Laquila, Italy

[7] Charite Univ Med Berlin, Expt & Clin Res Ctr, D-13125 Berlin, Germany

[8] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany

[9] German Canc Consortium DKTK, D-69120 Heidelberg, Germany

[10] Univ Tehran Med Sci, Roozbeh Hosp, Psychiat Res Ctr, Tehran 1416753955, Iran

[11] Howard Univ, Dept Anat, Coll Med, Neuropsychopharmacol Lab, Washington, DC 20059 USA

来源：

NUTRIENTS | 2019年 / 11卷 / 05期

基金：

美国国家卫生研究院;

关键词：

saffron; gastrointestinal diseases; microbiome; colon; stomach; liver; pancreas; inflammation; gastritis; hepatitis: pancreatitis; colitis; cancer; IRRITABLE-BOWEL-SYNDROME; CROCUS-SATIVUS-L; GASTRIC-CANCER; UNITED-STATES; IN-VITRO; CROCETIN; EXTRACT; LIVER; ADENOCARCINOMA; PREVALENCE;

D O I：

10.3390/nu11050943

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Saffron is a natural compound that has been used for centuries in many parts of the world as a food colorant and additive. It was shown to have the ability to mitigate various disorders through its known anti-inflammatory and anti-oxidant properties. Several studies have shown the effectiveness of saffron in the treatment of various chronic diseases like inflammatory bowel diseases, Alzheimer's, rheumatoid arthritis as well as common malignancies of the colon, stomach, lung, breast, and skin. Modern day drugs generally have unwanted side effects, which led to the current trend to use naturally occurring products with therapeutic properties. In the present review, the objective is to systematically analyze the wealth of information regarding the potential mechanisms of action and the medical use of saffron, the golden spice, especially in digestive diseases. We summarized saffron influence on microbiome, molecular pathways, and inflammation in gastric, colon, liver cancers, and associated inflammations.

引用

页数：16

共 63 条

[21] Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model [J].