Ethnic variation in medical and lifestyle risk factors for B cell non-Hodgkin lymphoma: A case-control study among Israelis and Palestinians

被引：14

作者：

Kleinstern, Geffen ^{[1
]}

Abu Seir, Rania ^{[2
,3
]}

Perlman, Riki ^{[2
]}

Khatib, Areej ^{[4
]}

Abdeen, Ziad ^{[5
]}

Elyan, Husein ^{[6
]}

Nirel, Ronit ^{[7
]}

Amir, Gail ^{[8
]}

Ramlawi, Asad ^{[9
]}

Sabatin, Fouad ^{[4
]}

Boffetta, Paolo ^{[10
,11
]}

Dann, Eldad J. ^{[12
,13
]}

Kedmi, Meirav ^{[14
,15
]}

Ellis, Martin ^{[16
]}

Nagler, Arnon ^{[14
,15
]}

Ben Yehuda, Dina ^{[2
]}

Paltiel, Ora ^{[1
,2
]}

机构：

[1] Hadassah Hebrew Univ Med Org, Sch Publ Hlth, Jerusalem, Israel

[2] Hadassah Hebrew Univ Med Ctr, Dept Hematol, Jerusalem, Israel

[3] Al Quds Univ, Dept Med Lab Sci, Fac Hlth Profess, Abu Deis, West Bank, Palestine

[4] Augusta Victoria Hosp, Canc Care Ctr, East Jerusalem, Palestine

[5] Al Quds Univ, Dept Community Med, Sch Fac Med, Abu Deis, West Bank, Palestine

[6] Beit Jalla Hosp, West Bank, PA, Palestine

[7] Hebrew Univ Jerusalem, Dept Stat, Jerusalem, Israel

[8] Hadassah Med Ctr, Dept Pathol, Jerusalem, Israel

[9] Minist Hlth, Dept Primary Hlth Care, Ramallah, Palestine

[10] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA

[11] Mt Sinai Sch Med, Inst Translat Epidemiol, New York, NY USA

[12] Technion, Rambam Med Ctr, Haifa, Israel

[13] Technion, Rappaport Fac Med, Haifa, Israel

[14] Chaim Sheba Med Ctr, Tel Hashomer, Israel

[15] Tel Aviv Univ, IL-69978 Tel Aviv, Israel

[16] Meir Med Ctr, Kefar Sava, Israel

来源：

PLOS ONE | 2017年 / 12卷 / 02期

关键词：

POOLED ANALYSIS; HEMATOLOGICAL MALIGNANCIES; ALCOHOL-CONSUMPTION; EPIDEMIOLOGY; COHORT; CLASSIFICATION; CONSORTIUM; INTERLYMPH; PATTERNS; EXPOSURE;

D O I：

10.1371/journal.pone.0171709

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background Risk factors for B-cell non-Hodgkin lymphoma (B-NHL) have not been assessed among Palestinian Arabs (PA) and Israeli Jews (IJ). Methods In a case-control study we investigated self-reported medical and lifestyle exposures, reporting odds ratios (ORs) and 95% confidence intervals [CIs], by ethnicity, for overall B-NHL and subtypes. Results We recruited 823 cases and 808 healthy controls. Among 307 PA/516 IJ B-NHL cases (mean age at diagnosis = 51 [+/- 17] versus 60 [+/- 15] years, respectively) subtype distributions differed, with diffuse large B-cell lymphoma (DLBCL) being prominent among PA (71%) compared to IJ (41%); follicular lymphoma (FL), was observed in 14% versus 28%, and marginal zone lymphoma, in 2% versus 14%, respectively. Overall B-NHL in both populations was associated with recreational sun exposure OR = 1.43 [CI: 1.07-1.91], black hair-dye use OR = 1.70 [CI: 1.00-2.87], hospitalization for infection OR = 1.68 [CI: 1.34-2.11], and first-degree relative with hematopoietic cancer, OR = 1.69 [CI: 1.16-2.48]. An inverse association was noted with alcohol use, OR = 0.46 [CI: 0.34-0.62]. Subtype-specific exposures included smoking (FL, OR = 1.46 [CI: 1.01-2.11]) and > monthly indoor pesticide use (DLBCL, OR = 2.01 [CI: 1.35-3.00]). Associations observed for overall B-NHL in PA only included: gardening OR = 1.93 [CI: 1.39-2.70]; history of herpes, mononucleosis, rubella, blood transfusion (OR> 2.5, P< 0.01 for all); while for IJ risk factors included growing fruits and vegetables, OR = 1.87 [CI: 1.11-3.15]; and self-reported autoimmune diseases, OR = 1.99 [CI: 1.34-2.95]. Conclusions In these geographically proximate populations we found some unique risk factors for B-NHL. Heterogeneity in the observed associations by ethnicity could reflect differences in lifestyle, medical systems, and reporting patterns, while variations by histology infer specific etiologic factors for lymphoma subtypes.

引用

页数：12

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