Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance

被引：81
|
作者：
Ge, Rongbin [1 ]
Wang, Zongwei [2 ]
Cheng, Liang [1 ,3 ]
机构：
[1] Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA
[2] Harvard Med Sch, Div Urol Surg, Dept Surg, Beth Israel Deaconess Med Ctr, Boston, MA USA
[3] Indiana Univ Sch Med, Dept Urol, Indianapolis, IN 46202 USA
来源：
NPJ PRECISION ONCOLOGY | 2022年 / 6卷 / 01期
关键词：
HYPOXIA-INDUCIBLE FACTORS; FACTORS MASTER REGULATORS; TGF-BETA; T-CELLS; MESENCHYMAL TRANSITION; CLONAL EVOLUTION; STEM-CELLS; BLOOD-FLOW; FIBROBLASTS; EXPRESSION;
D O I：
10.1038/s41698-022-00272-w
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Prostate cancer is characterized by a high degree of heterogeneity, which poses a major challenge to precision therapy and drug development. In this review, we discuss how nongenetic factors contribute to heterogeneity of prostate cancer. We also discuss tumor heterogeneity and phenotypic switching related to anticancer therapies. Lastly, we summarize the challenges targeting the tumor environments, and emphasize that continued exploration of tumor heterogeneity is needed in order to offer a personalized therapy for advanced prostate cancer patients.
引用
收藏
页数：8
相关论文
共 50 条
  • [1] Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance
    Rongbin Ge
    Zongwei Wang
    Liang Cheng
    npj Precision Oncology, 6
  • [2] Tumor microenvironment promotes cancer progression, metastasis, and therapeutic resistance
    Sung, Shian-Ying
    Johnstone, Peter A. S.
    CURRENT PROBLEMS IN CANCER, 2007, 31 (02) : 36 - 100
  • [3] Regulation of prostate cancer progression by the tumor microenvironment
    Shiao, Stephen L.
    Chu, Gina Chia-Yi
    Chung, Leland W. K.
    CANCER LETTERS, 2016, 380 (01) : 340 - 348
  • [4] Characterization of the tumor microenvironment in prostate cancer progression
    Bonollo, F.
    Cheng, W.
    Sampson, N.
    Chouvardas, P.
    Thalmann, G.
    Kruithof-De Julio, M.
    Karkampouna, S.
    EUROPEAN UROLOGY, 2024, 85 : S1437 - S1437
  • [5] Sex steroids in the tumor microenvironment and prostate cancer progression
    Boibessot, Clovis
    Toren, Paul
    ENDOCRINE-RELATED CANCER, 2018, 25 (03) : R179 - R196
  • [6] The Role of the Tumor Microenvironment in Triple-Positive Breast Cancer Progression and Therapeutic Resistance
    Pu, Qian
    Gao, Haidong
    CANCERS, 2023, 15 (22)
  • [7] Role of tumor microenvironment in cancer progression and therapeutic strategy
    Wang, Qingjing
    Shao, Xueting
    Zhang, Yuxuan
    Zhu, Miaojin
    Wang, Frederick X. C.
    Mu, Jianjian
    Li, Jiaxuan
    Yao, Hangping
    Chen, Keda
    CANCER MEDICINE, 2023, 12 (10): : 11149 - 11165
  • [8] Glioblastoma Tumor Microenvironment: An Important Modulator for Tumoral Progression and Therapy Resistance
    Tataranu, Ligia Gabriela
    Turliuc, Serban
    Kamel, Amira
    Rizea, Radu Eugen
    Dricu, Anica
    Staicu, Georgiana-Adeline
    Baloi, Stefania Carina
    Rodriguez, Silvia Mara Baez
    Manole, Andrada Ioana Maria
    CURRENT ISSUES IN MOLECULAR BIOLOGY, 2024, 46 (09) : 9881 - 9894
  • [9] RISING STARS: Heterogeneity and the tumor microenvironment in neuroendocrine prostate cancer
    Brady, Lauren
    Nelson, Peter S.
    JOURNAL OF ENDOCRINOLOGY, 2023, 256 (02)
  • [10] NETs: Important players in cancer progression and therapeutic resistance
    Guan, Xiaoying
    Guan, Xiaoli
    Zhao, Zhiqiang
    Yan, Hong
    EXPERIMENTAL CELL RESEARCH, 2024, 441 (02)
12345