Genetic diversity and phylogeny of Mycobacterium avium

被引:83
作者
Rindi, Laura [1 ]
Garzelli, Carlo [1 ]
机构
[1] Univ Pisa, Dipartimento Ric Traslaz & Nuove Tecnol Med & Chi, I-56127 Pisa, Italy
关键词
M. avium subsp hominissuis; M. avium subsp avium; M. avium subsp silvaticum; M. avium subsp paratuberculosis; Genomic polymorphism; Mycobacterial phylogeny; FRAGMENT-LENGTH-POLYMORPHISM; NUMBER TANDEM-REPEAT; SUBSP-PARATUBERCULOSIS; INSERTION ELEMENT; CROHNS-DISEASE; NONTUBERCULOUS MYCOBACTERIA; SP-NOV; SEQUENCE POLYMORPHISMS; MOLECULAR EPIDEMIOLOGY; DNA HYBRIDIZATION;
D O I
10.1016/j.meegid.2013.12.007
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Mycobacterium avium, one of the species of the M. avium complex (MAC), includes 4 subspecies, i.e., M. avium subsp. hominissuis (MAH), M. avium subsp. avium (MAA), M. avium subsp. silvaticum (MAS) and M. avium subsp. paratuberculosis (MAP), in turn classified into the S (sheep) and C (cattle) types. These subspecies, although closely related, represent distinct organisms, each endowed with specific pathogenetic and host range characteristics, ranging from environmental opportunistic bacteria that cause infections in swine and immunocompromised patients to pathogens of birds and ruminants. The present review summarizes the basic epidemiological and pathological features of the M. avium subspecies, describes the major genomic events responsible of M. avium subspecies diversity (insertion sequences, sequence variations in specific chromosome loci or genes, deletions, duplications and insertions of large genomic regions) and then reconstructs the phylogenetic relationships among the M. avium subspecies. (C) 2013 Elsevier B. V. All rights reserved.
引用
收藏
页码:375 / 383
页数:9
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