Organization and functions of sphingolipid biosynthesis in yeast

被引：10

作者：

Riezman, H. ^{[1
]}

机构：

[1] Univ Geneva, Dept Biochem, CH-1211 Geneva 4, Switzerland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2006年 / 34卷

关键词：

ceramide synthase; endoplasmic reticulum; inositolphosphorylceramide; serine palmitoyltransferase; sphingolipid biosynthesis; yeast;

D O I：

10.1042/BST0340367

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sphingolipids are important signalling molecules and thus it is very important to understand how they are generated. Sphingolipid biosynthesis shows a conserved compartmentalization in eukaryotic cells. Their synthesis begins in the endoplasmic reticulum and is completed in the Golgi apparatus. We now know quite a bit about the topology of the reactions in the pathway, but certain critical steps, such as ceramide synthesis, are still poorly understood. in the present paper, we discuss the latest views on this subject.

引用

页码：367 / 369

页数：3

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