Variants in ANRIL gene correlated with its expression contribute to myocardial infarction risk

被引：38

作者：

Cheng, Jie ^{[1
,2
]}

Cai, Meng-Yun ^{[1
,3
]}

Chen, Yu-Ning ^{[1
,3
]}

Li, Zhi-Cheng ^{[1
,3
]}

Tang, Sai-Sai ^{[1
,3
]}

Yang, Xi-Li ^{[4
]}

Chen, Can ^{[5
]}

Liu, Xinguang ^{[1
,3
,6
]}

Xiong, Xing-dong ^{[1
,3
,6
]}

机构：

[1] Guangdong Med Univ, Inst Aging Res, Dongguan, Peoples R China

[2] Guangdong Med Univ, Affiliated Hosp, Dept Clin Lab, Zhanjiang, Peoples R China

[3] Guangdong Med Univ, Guangdong Prov Key Lab Med Mol Diagnost, Dongguan, Peoples R China

[4] First Peoples Hosp Foshan, Dept Cardiovasc Dis, Foshan, Peoples R China

[5] Guangdong Med Univ, Affiliated Hosp, Dept Cardiovasc Dis, Zhanjiang, Peoples R China

[6] Guangdong Med Univ, Inst Biochem & Mol Biol, Zhanjiang, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 08期

基金：

中国国家自然科学基金;

关键词：

ANRIL; single nucleotide polymorphism; myocardial infarction; risk; Gerotarget; CORONARY-ARTERY-DISEASE; CHROMOSOME; 9P21; LOCUS; 4; SNPS; ASSOCIATION ANALYSIS; POPULATION; ATHEROSCLEROSIS; SUSCEPTIBILITY; POLYMORPHISM; GENOME; REPLICATION;

D O I：

10.18632/oncotarget.14721

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

ANRIL (antisense non-coding RNA in the INK4 locus), located at the 9p21.3 locus, has been known to be closely associated with the risk of coronary artery disease (CAD). To date, studies of the 9p21.3 variants on CAD risk mainly focus on the non-coding region of ANRIL. However, the biological significance of the variants on ANRIL promoter and exons is still unknown. Here we investigate whether the variants on ANRIL promoter and exons have an effect on myocardial infarction (MI) risk, and further analyze the association of these variants with the expression of ANRIL transcript. We did not find any common variants with minor allele frequencies (MAF) larger than 5% in ANRIL promoter by sequencing 1.6kb upstream of the start codon. Unconditional logistic regression analysis revealed that two SNPs in ANRIL exons, rs10965215 and rs10738605, were significantly associated with MI risk. Further studies revealed that ANRIL transcript EU741058.1 expression levels of rs10965215 and rs10738605 risk genotypes were borderline lower than those of protective genotypes. Our data provide the evidence that the variants rs10965215 and rs10738605 in ANRIL exons contribute to MI risk in the Chinese Han population which might be correlated with the expression of its transcript EU741058.1.

引用

页码：12607 / 12619

页数：13

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