Determination of Tetracyclines in Milk by Graphene-Based Solid-Phase Extraction and High-Performance Liquid Chromatography

被引：34
作者：
Wu, Xia Jun [1 ]
Wang, Geng Nan [1 ]
Yang, Kun [1 ]
Liu, Hui Zhi [1 ]
Wang, Jian Ping [1 ]
机构：
[1] Agr Univ Hebei, Coll Vet Med, Lekai South St 2596, Baoding 071000, Hebei, Peoples R China
来源：
ANALYTICAL LETTERS | 2017年 / 50卷 / 04期
关键词：
Graphene; high-performance liquid chromatography; milk; solid-phase extraction; tetracyclines; TANDEM MASS-SPECTROMETRY; ENVIRONMENTAL WATER SAMPLES; MULTI-RESIDUE ANALYSIS; BOVINE-MILK; CARBAMATE PESTICIDES; SCREENING METHOD; ANTIBIOTICS; VALIDATION; OXYTETRACYCLINE; NANOCOMPOSITE;
D O I：
10.1080/00032719.2016.1194853
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A graphene-based solid-phase extraction (SPE) column was prepared for the isolation of tetracyclines from milk followed by determination by high-performance liquid chromatography. Graphene provided better separation for tetracyclines than amine-modified graphene and carboxyl-modified graphene. The optimized graphene-based SPE column showed high absorption capacities (greater than 4,660 ng) and high recoveries (exceeding 92%) for tetracycline, oxytetracycline, chlortetracycline, and doxycycline and was successfully reused at least fifty times. The limits of detection in milk were from 10 to 20 ng/mL, with recoveries between 82.3 and 103.6%. Furthermore, the system showed superior performance than two commercial SPE cartridges with respect to recovery, purification, and reusability. Therefore, this approach is suitable for the determination of tetracyclines in milk.
引用
收藏
页码：641 / 650
页数：10
相关论文
共 30 条
  • [1] Preparation of Antibodies and Development of an Enzyme-Linked Immunosorbent Assay (ELISA) for the Determination of Doxycycline Antibiotic in Milk Samples
    Adrian, Javier
    Fernandez, Fatima
    Sanchez-Baeza, Francisco
    Marco, M. -Pilar
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2012, 60 (15) : 3837 - 3846
  • [2] Screening for tetracycline residues in food products of animal origin in the State of Kuwait using Charm II radio-immunoassay and LC/MS/MS methods
    Al-Mazeedi, Hani M.
    Abbas, Alaa B.
    Alomirah, Hussam F.
    Al-Jouhar, Wafaa Y.
    Al-Mufty, Siham A.
    Ezzelregal, Mohamed M.
    Al-Owaish, Rashed A.
    [J]. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2010, 27 (03): : 291 - 301
  • [3] Graphene-based Magnetic Solid Phase Extraction-Dispersive Liquid Liquid Microextraction Combined with Gas Chromatographic Method for Determination of Five Acetanilide Herbicides in Water and Green Tea Samples
    Bai Sha-Sha
    Li Zhi
    Zang Xiao-Huan
    Wang Chun
    Wang Zhi
    [J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2013, 41 (08) : 1177 - 1182
  • [4] Multiclass screening method based on solvent extraction and liquid chromatography-tandem mass spectrometry for the determination of antimicrobials and mycotoxins in egg
    Capriotti, Anna Laura
    Cavaliere, Chiara
    Piovesana, Susy
    Samperi, Roberto
    Lagana, Aldo
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2012, 1268 : 84 - 90
  • [5] Preparation and evaluation of graphene-coated solid-phase microextraction fiber
    Chen, Jinmei
    Zou, Jing
    Zeng, Jingbin
    Song, Xinhong
    Ji, Jiaojiao
    Wang, Yiru
    Ha, Jaeho
    Chen, Xi
    [J]. ANALYTICA CHIMICA ACTA, 2010, 678 (01) : 44 - 49
  • [6] Application of graphene-based solid-phase extraction for ultra-fast determination of malachite green and its metabolite in fish tissues
    Chen, Linyao
    Lu, Yanbin
    Li, Shiyao
    Lin, Xianjiang
    Xu, Zhongming
    Dai, Zhiyuan
    [J]. FOOD CHEMISTRY, 2013, 141 (02) : 1383 - 1389
  • [7] Quantitative multi-residue analysis of tetracyclines and their 4-epimers in pig tissues by high-performance liquid chromatography combined with positive-ion electrospray ionization mass spectrometry
    Cherlet, M
    Schelkens, M
    Croubels, S
    De Backer, P
    [J]. ANALYTICA CHIMICA ACTA, 2003, 492 (1-2) : 199 - 213
  • [8] Validation of a high-performance liquid chromatography method for the determination of oxytetracycline, tetracycline, chlortetracycline and doxycycline in bovine milk and muscle
    Cinquina, AL
    Longo, F
    Anastasi, G
    Giannetti, L
    Cozzani, R
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2003, 987 (1-2) : 227 - 233
  • [9] Preparation of molecularly imprinted nanoparticles with superparamagnetic susceptibility through atom transfer radical emulsion polymerization for the selective recognition of tetracycline from aqueous medium
    Dai, Jiangdong
    Pan, Jianming
    Xu, Longcheng
    Li, Xiuxiu
    Zhou, Zhiping
    Zhang, Rongxian
    Yan, Yongsheng
    [J]. JOURNAL OF HAZARDOUS MATERIALS, 2012, 205 : 179 - 188
  • [10] Isolation of tetracyclines in milk using a solid-phase extracting column and water eluent
    Furusawa, N
    [J]. TALANTA, 2003, 59 (01) : 155 - 159
123