Clinical and molecular epidemiology of community-onset invasive Staphylococcus aureus infection in New Zealand children

被引：12

作者：

Williamson, D. A. ^{[1
,2
,3
]}

Ritchie, S. R. ^{[1
]}

Roberts, S. A. ^{[2
]}

Coombs, G. W. ^{[4
,5
]}

Thomas, M. G. ^{[1
]}

Hannaford, O. ^{[6
]}

Baker, M. G. ^{[7
]}

Lennon, D. ^{[1
]}

Fraser, J. D. ^{[1
]}

机构：

[1] Univ Auckland, Fac Med & Hlth Sci, Auckland 1, New Zealand

[2] Auckland Dist Hlth Board, Dept Clin Microbiol, Auckland, New Zealand

[3] Inst Environm Sci & Res, Wellington, New Zealand

[4] Australian Collaborating Ctr Enterococcus & Staph, PathWest Lab Med, Perth, WA, Australia

[5] Curtin Univ, Sch Biomed Sci, Perth, WA 6845, Australia

[6] Massey Univ, NZIAS, Dept Stat, Albany, New Zealand

[7] Univ Otago, Dept Publ Hlth, Wellington, New Zealand

来源：

EPIDEMIOLOGY AND INFECTION | 2014年 / 142卷 / 08期

关键词：

Paediatrics; Staphylococcus aureus; statistics; PANTON-VALENTINE LEUKOCIDIN; METHICILLIN-RESISTANT; PATHOGENESIS; POPULATION; BACTEREMIA; STRAINS; SKIN;

D O I：

10.1017/S0950268814000053

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Our aim was to describe the epidemiology and incidence of community-onset invasive S. aureus disease in children presenting to our hospital, and to compare the clonal complexes and virulence genes of S. aureus strains causing invasive and non-invasive disease. The virulence gene repertoire of invasive disease isolates was characterized using DNA microarray and compared with the virulence gene repertoire of non-invasive S. aureus isolates. Over the study period, 163 children had an invasive S. aureus infection. There was no difference in the distribution of clonal complexes or in the prevalence of genes encoding virulence factors between invasive and non-invasive isolates. Future research should include a strong focus on identifying the host and environmental factors that, along with organism virulence factors, are contributing to the patterns of invasive S. aureus disease observed in New Zealand.

引用

页码：1713 / 1721

页数：9

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