Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations
被引:46
作者:
Akagi, Tadayuki
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Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA
Akagi, Tadayuki
[1
]
Shih, Lee-Yung
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机构:
Chang Gung Mem Hosp, Dept Internal Med, Div Hematol Oncol, Taipei 10591, Taiwan
Chang Gung Univ, Sch Med, Tao Yuan, TaiwanUniv Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA
Shih, Lee-Yung
[2
,3
]
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h-index:
机构:
Kato, Motohiro
[4
]
Kawamata, Norihiko
论文数: 0引用数: 0
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机构:
Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA
Kawamata, Norihiko
[1
]
Yamamoto, Go
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机构:
Univ Tokyo, Dept Hematol & Oncol, Tokyo, Japan
Univ Tokyo, Grad Sch Med, 21st Century COE Program, Tokyo, JapanUniv Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA
Yamamoto, Go
[4
,5
]
Sanada, Masashi
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机构:
Univ Tokyo, Dept Hematol & Oncol, Tokyo, Japan
Univ Tokyo, Grad Sch Med, 21st Century COE Program, Tokyo, JapanUniv Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA
Sanada, Masashi
[4
,5
]
Okamoto, Ryoko
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Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA
Okamoto, Ryoko
[1
]
Miller, Carl W.
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Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA
Miller, Carl W.
[1
]
Liang, Der-Cherng
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机构:
Mackay Mem Hosp, Div Pediat Hematol Oncol, Taipei, TaiwanUniv Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA
Liang, Der-Cherng
[6
]
Ogawa, Seishi
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机构:
Univ Tokyo, Dept Hematol & Oncol, Tokyo, JapanUniv Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA
Ogawa, Seishi
[4
]
Koeffler, H. Phillip
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Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USAUniv Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA
Koeffler, H. Phillip
[1
]
机构:
[1] Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA
[2] Chang Gung Mem Hosp, Dept Internal Med, Div Hematol Oncol, Taipei 10591, Taiwan
[3] Chang Gung Univ, Sch Med, Tao Yuan, Taiwan
[4] Univ Tokyo, Dept Hematol & Oncol, Tokyo, Japan
[5] Univ Tokyo, Grad Sch Med, 21st Century COE Program, Tokyo, Japan
[6] Mackay Mem Hosp, Div Pediat Hematol Oncol, Taipei, Taiwan
ACUTE MYELOID-LEUKEMIA;
PML-RAR-ALPHA;
INTERNAL TANDEM DUPLICATION;
ACQUIRED UNIPARENTAL DISOMY;
RETINOIC ACID;
NORMAL KARYOTYPE;
CELL-LINE;
T(15-17) TRANSLOCATION;
SIGNAL-TRANSDUCTION;
PML/RAR-ALPHA;
D O I:
10.1182/blood-2007-12-130260
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Acute promyelocytic leukemia (APL) is ahematopoietic malignant disease characterized by the chromosomal translocation t(15; 17), resulting in the formation of the PML-RARA gene. Here, 47 t(15; 17) APL samples were analyzed with high-density single-nucleotide polymorphism microarray (50-K and 250-K SNP-chips) using the new algorithm AsCNAR (allele-specific copy-number analysis using anonymous references). Copy-number-neutral loss of heterozygosity (CNN-LOH) was identified at chromosomes 10q(3 cases), 11p (3 cases), and 19q (1 case). Twenty-eight samples (60%) did not have an obvious alteration (normal-copy-number [NC] group). Nineteen samples (40%) showed either one or more genomic abnormalities: 8 samples (17%) had trisomy 8 either with or without an additional duplication, deletion, or CNN-LOH (+ 8 group); and 11 samples (23%) had genomic abnormalities without trisomy 8 (other abnormalities group). These chromosomal abnormalities were acquired somatic mutations. Interestingly, FLT3-ITD mutations (11/47 cases) occurred only in the group with no genomic alteration (NC group). Taken together, these results suggest that the pathway of development of APL differs in each group: FLT3-ITD, trisomy 8, and other genomic changes. Here, we showed for the first time hidden abnormalities and novel disease-related genomic changes in t(15; 17) APL. (Blood. 2009; 113: 1741-1748)