Four cases of cell cannibalism in highly malignant feline and canine tumors

被引：4

作者：

Ferreira, Fernando Costa ^{[1
]}

Soares, Maria Joao ^{[1
]}

Carvalho, Sandra ^{[1
]}

Borralho, Liliana ^{[2
]}

Vicente, Goncalo ^{[3
]}

Branco, Sandra ^{[4
]}

Correia, Jorge ^{[1
]}

Peleteiro, Maria Conceicao ^{[1
]}

机构：

[1] Univ Lisbon, Fac Med Vet, Interdisciplinary Ctr Res Anim Hlth, CIISA, P-1300477 Lisbon, Portugal

[2] Clin Vet Oriente, P-1990176 Lisbon, Portugal

[3] Univ Lisbon, Fac Vet Med, Vet Teaching Hosp, P-1300477 Lisbon, Portugal

[4] Univ Evora, ICAAM Inst Mediterranean Agrarian & Environm Sci, P-7006554 Evora, Portugal

来源：

DIAGNOSTIC PATHOLOGY | 2015年 / 10卷

关键词：

Cell cannibalism; Neoplasia; Carcinoma; Mesothelioma; Cytokeratin; E-cadherin; E-CADHERIN; EXPRESSION; ENTOSIS;

D O I：

10.1186/s13000-015-0429-3

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Four cases of tumors in which cell internalization was frequently visualized are reported: one feline mammary carcinoma, one feline cutaneous squamous cell carcinoma, one canine pulmonary squamous cell carcinoma and one canine pleural mesothelioma. Cell internalization was observed by cytology in two of these cases (the feline mammary tumour and the pleural effusion in the canine mesothelioma) and by histopathology in all but the canine mesothelioma. Immunohistochemical staining for pancytokeratin was positive for both internalized and host cells, while E-cadherin expression was frequently absent, although internalized cells occasionally stained positive. This cell-to-cell interaction seems to be associated with tumors displaying a strong epithelial-mesenchymal transitional phenotype, in which cancer cells become engulfed by other cancer cells. Such event could be regarded as an important hallmark of very high malignancy.

引用

页数：6

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