Investigation of volumetric apparent diffusion coefficient histogram analysis for assessing complete response and clinical outcomes following pre-operative chemoradiation treatment for rectal carcinoma

被引：20

作者：

Chidambaram, Vijay ^{[1
]}

Brierley, James D. ^{[2
]}

Cummings, Bernard ^{[2
]}

Bhayana, Rajesh ^{[3
]}

Menezes, Ravi J. ^{[4
]}

Kennedy, Erin D. ^{[5
]}

Kirsch, Richard ^{[6
]}

Jhaveri, Kartik S. ^{[7
,8
,9
]}

机构：

[1] Royal Liverpool & Broadgreen Univ Hosp, NHS Trust, Prescot St, Liverpool L7 8XP, Merseyside, England

[2] Univ Toronto, Princess Margaret Canc Ctr, Princess Margaret Hosp, Dept Radiat Oncol, 610 Univ Ave, Toronto, ON M5G 2M9, Canada

[3] Univ Toronto, Dept Med Imaging, JDMI Res, 2nd Floor,700 Univ Ave, Toronto, ON M5G 1X6, Canada

[4] Univ Hlth Network, Joint Dept Med Imaging, JDMI Res, 2nd Floor,700 Univ Ave, Toronto, ON M5G 1X6, Canada

[5] Univ Toronto, Mt Sinai Hosp, Div Gen Surg, 600 Univ Ave, Toronto, ON M5G 1X5, Canada

[6] Univ Toronto, Mt Sinai Hosp, Pathol & Lab Med Dept, 600 Univ Ave Rm 6-500-10, Toronto, ON M5G 1X5, Canada

[7] Univ Hlth Network, Mt Sinai Hosp, Joint Dept Med Imaging, 610 Univ Ave,3-957, Toronto, ON M5G 2M9, Canada

[8] Univ Toronto, Womens Coll Hosp, 610 Univ Ave,3-957, Toronto, ON M5G 2M9, Canada

[9] Univ Toronto, Princess Margaret Hosp, Dept Radiol, 610 Univ Ave,3-957, Toronto, ON M5G 2M9, Canada

来源：

ABDOMINAL RADIOLOGY | 2017年 / 42卷 / 05期

关键词：

Rectal carcinoma; Diffusion-weighted MRI; Apparent diffusion coefficient (ADC); Chemoradiation treatment (CRT); QUALITY-OF-LIFE; RADIATION-THERAPY; CERVICAL-CANCER; MR VOLUMETRY; RADIOTHERAPY; CHEMOTHERAPY; RECURRENCE;

D O I：

10.1007/s00261-016-1010-6

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To investigate the relationship of pre-treatment volumetric apparent diffusion coefficient (ADC) histogram parameters with post-operative histopathologic treatment response and clinical outcomes following pre-operative chemoradiation treatment (CRT) in rectal cancer. Materials and methods: In a Health Insurance Portability and Accountability Act compliant retrospective study, 78 rectal cancer patients treated with pre-operative CRT and rectal MRI were included. MR imaging analysis was performed using OncoTREAT (software tool). Multiple volumetric ADC histogram parameters (voxel distribution across ADC ranges, kurtosis, and skewness) were assessed. Correlation was made to post-operative pathological complete response, clinical, or radiological evidence of disease progression using the Mann-Whitney test. Results: Post CRT, 8 patients showed pathologic complete response and 13 patients showed distant disease progression. Pre-treatment mean ADC was 1.2 9 10(-3) mm(2)/s (range 0.3-1.99 9 10(-3) mm(2)/s). Mean kurtosis measured was 0.56 (range -1 to 6; SD 1.36). Mean skewness was 0.3 (range -1 to 2; SD 0.69). Skewness had significant correlation (p value = 0.006) with disease progression. The mean rectal tumor volume was 24cc (range 1cc-134cc). Pre-treatment MRI tumor volume showed significant correlation (p value = 0.013) with pathologic complete response. Mean ADC and percentage voxels distribution against ADC ranges had no significant correlation with treatment response or disease outcomes. Conclusion: Volumetric ADC histogram analysis of pre-CRT rectal cancer MRI appears promising for prediction of post-CRT complete response and disease progression.

引用

页码：1310 / 1318

页数：9

共 39 条

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