(Pro)insulin processing - A historical perspective

被引：39

作者：

Davidson, HW ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80202 USA

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2004年 / 40卷 / Suppl 3期

关键词：

proinsulin; insulin; convertase;

D O I：

10.1385/CBB:40:3:143

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insulin, the major secreted product of the beta-cells of the islets of Langerhans, is initially synthesized as a precursor (preproinsulin), from which the mature hormone is excised by a series of proteolytic cleavages. This review provides a personal narrative of some of the key research projects leading to the identification of the central processing enzymes as proprotein convertase 1, proprotein convertase 2, and carboxypeptidase E. It also discusses the central roles of the intragranular environment and chaperone-like proteins in modulating processing activity.

引用

页码：143 / 157

页数：15

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