Topical delivery of dexamethasone acetate from hydrogel containing nanostructured liquid carriers and the drug

被引：3
作者：
Nguyen-Thach Tung [2 ]
Vu-Thu Huyen [2 ]
Chi, Sang-Cheol [1 ]
机构：
[1] Gachon Univ, Coll Pharm, Hambakmoeiro 191, Inchon 406799, South Korea
[2] Hanoi Univ Pharm, Dept Pharmaceut, 13-15 Thanh Tong, Hanoi, Vietnam
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2015年 / 38卷 / 11期
关键词：
Dexamethasone acetate; Nanostructured lipid carrier; Hydrogel; Skin deposition; Permeation rate; SOLID LIPID NANOPARTICLES; PENETRATION ENHANCERS; SKIN; MELOXICAM; RELEASE; DESIGN; SYSTEM; NLC; GEL;
D O I：
10.1007/s12272-015-0608-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The potential of hydrogel containing nanostructured lipid carriers (NLC) to enhance the skin permeation rate and skin deposition of dexamethasone acetate (DEA) was investigated. The particle size of obtained NLCs was around 224.4 nm. NLCs had core-shell structure and DEA existed in amorphous state in NLCs. The permeation rate of DEA through excised mouse skins from hydrogel containing DEA-NLC (DEA-NLC-hydrogel) was 7.3 times higher than DEA-ointment. The skin deposition of DEA from DEA-NLC-hydrogel increased 3.8 folds compared to that from solution of DEA in hydrogel (DEA-hydrogel).
引用
收藏
页码：1999 / 2007
页数：9
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