Factors Associated With Recurrence of Cervical Intraepithelial Neoplasia 2+ After Treatment Among HIV-Infected Women in Western Kenya

被引：17

作者：

Huchko, Megan J. ^{[1
]}

Leslie, Hannah ^{[2
]}

Maloba, May ^{[3
]}

Bukusi, Elizabeth A. ^{[3
]}

Cohen, Craig R. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94105 USA

[2] Univ Calif Berkeley, Dept Epidemiol, Berkeley, CA 94720 USA

[3] Kenya Govt Med Res Ctr, Nairobi, Kenya

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2014年 / 66卷 / 02期

基金：

美国国家卫生研究院;

关键词：

cervical cancer prevention; HIV; women's global health; Kenya; loop electrosurgical excision procedure; treatment recurrence; HUMAN-IMMUNODEFICIENCY-VIRUS; ELECTROSURGICAL EXCISION PROCEDURE; HUMAN-PAPILLOMAVIRUS; RISK; DISEASE; LESIONS; COHORT; HAART;

D O I：

10.1097/QAI.0000000000000130

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV-infected women are at increased risk for recurrence of cervical dysplasia after treatment. Short-term recurrence rates may reflect treatment efficacy and therefore impact screening protocols and follow-up planning. We conducted a prospective study of 297 HIV-infected women undergoing loop electrosurgical excision procedure for cervical intraepithelial neoplasia 2+ (CIN2+) in an HIV clinic in Kisumu, Kenya. By 6 months after the procedure, 20 (7.1%) of women had recurrent CIN2+. Recurrence was significantly associated with CD4(+) nadir but not with highly active antiretroviral therapy use. Longer-term follow-up of this cohort will illustrate the potential impact of highly active antiretroviral therapy and immune status on CIN2/3 disease recurrence.

引用

页码：188 / 192

页数：5

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