Immunogenicity and safety of a trivalent inactivated 2010-2011 influenza vaccine in Taiwan infants aged 6-12 months

被引：5

作者：

Hwang, Kao-Pin ^{[1
,6
]}

Hsu, Yu-Lung ^{[1
]}

Hsieh, Tsung-Hsueh ^{[1
]}

Lin, Hsiao-Chuan ^{[1
]}

Yen, Ting-Yu ^{[1
]}

Wei, Hsiu-Mei ^{[1
]}

Lin, Hung-Chih ^{[2
]}

Chen, An-Chyi ^{[3
]}

Chow, Julie Chi ^{[4
]}

Huang, Li-Min ^{[5
]}

机构：

[1] China Med Univ Hosp, Dept Pediat, Div Pediat Infect Dis, Taichung, Taiwan

[2] China Med Univ Hosp, Div Neonatol, Dept Pediat, Taichung, Taiwan

[3] China Med Univ Hosp, Dept Pediat, Taichung, Taiwan

[4] Chi Mei Med Ctr, Dept Pediat, Tainan, Taiwan

[5] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Pediat, Taipei 10764, Taiwan

[6] China Med Univ, Sch Med, Taichung 404, Taiwan

来源：

VACCINE | 2014年 / 32卷 / 21期

关键词：

Children; Infant; Influenza; Influenza vaccine; Immunogenicity; Safety; CHILDREN; 6; IMMUNIZATION; VIRUS;

D O I：

10.1016/j.vaccine.2014.02.078

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This prospective study aimed to investigate the immune responses and safety of an influenza vaccine in vaccine-naive infants aged 6-12 months, and was conducted from November 2010 to May 2011. Fifty-nine infants aged 6-12 months received two doses of trivalent inactivated influenza vaccine 4 weeks apart. Hemagglutination inhibition titers were measured 4 weeks after the two doses of study vaccine. Based on the assumption that a hemagglutination inhibition titer of 1:40 or greater against the antigen would be protective in adults, two doses of the study vaccine generated a protective immune response of 63.2% against influenza A(H1N1), 82.5% against influenza A(H3N2) and 38.6% against influenza B viruses in infants aged 6-12 months. The geometric mean fold rises against influenza type A and B viruses also met the European Medicines Agency criteria for flu vaccines. The solicited events within 7 days after vaccination were mild in intensity. No deaths or adverse events such as optic neuritis, cranial neuropathy, and brachial neuropathy or Guillain-Barre syndrome were reported. Two doses of inactivated influenza vaccine were well tolerated and induced a protective immune response against influenza in infants aged 6-12 months. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：2469 / 2473

页数：5

共 21 条

[1] Influenza vaccine effectiveness in healthy 6- to 21-month-old children during the 2003-2004 season [J].