Acute lymphoblastic leukemia in infants

被引：0

作者：

Gürgey, A ^{[1
]}

Yetgin, S

Çetin, M

Gümrük, F

Tuncer, AM

Tunçbilek, E

Hiçsönmez, G

机构：

[1] Hacettepe Univ, Fac Med, Dept Pediat, Sect Hematol, TR-06100 Ankara, Turkey

[2] Hacettepe Univ, Fac Med, Dept Pediat, Genet Sect, TR-06100 Ankara, Turkey

来源：

TURKISH JOURNAL OF PEDIATRICS | 2004年 / 46卷 / 02期

关键词：

infant leukemia; acute lymphoblastic leukemia; high-dose methylprednisolone;

D O I：

暂无

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Between January 1978 and August 1999, 29 infants with newly diagnosed acute lymphoblastic leukemia (ALL) were treated on three consecutive protocols. Eighteen patients with infant ALL diagnosed between 1978-1991 were included in Group 1. In this group, treatment comprised a two-or three-drug induction with prednisolone, vincristine and L-asparaginase, and maintenance therapy consisted of weekly oral administration of mercaptopurine and methotrexate for three years. Group 2: Between 1991 and 1999, 11 infants with ALL were treated by St. Jude Total Therapy XI (n = 4) and XIII (n = 7) protocols with minor modification. Three years' event-free survival (SE) was 14+/-9% in group 1. In group 2, this rate was 25+/-22% in Total XI and 57+/-19% in Total XIII. Outcome for infants on protocols Total Therapy XI and XIII improved compared with that of group 1.

引用

页码：115 / 119

页数：5

共 14 条

[1] Biological and therapeutic aspects of infant leukemia [J].

Biondi, A ;

Cimino, G ;

Pieters, R ;

Pui, CH .

BLOOD, 2000, 96 (01) :24-33

[2]

CHESSELLS JM, 1994, LEUKEMIA, V8, P1275

[3] Treatment of infants with lymphoblastic leukaemia: results of the UK Infant Protocols 1987-1999 [J].

Chessells, JM ;

Harrison, CJ ;

Watson, SL ;

Vora, AJ ;

Richards, SM .

BRITISH JOURNAL OF HAEMATOLOGY, 2002, 117 (02) :306-314

[4] Multigenetic lesions in infant acute leukaemias: Correlations with ALL-1 gene status [J].

Cimino, G ;

Lanza, C ;

Elia, L ;

LoCoco, F ;

Gaidano, G ;

Biondi, A ;

Pastore, C ;

Serra, A ;

Canaani, E ;

Croce, CM ;

Mandelli, F ;

Saglio, G .

BRITISH JOURNAL OF HAEMATOLOGY, 1997, 96 (02) :308-313

[5] IMPROVED SURVIVAL FOR ACUTE LYMPHOBLASTIC-LEUKEMIA IN INFANCY - THE EXPERIENCE OF EORTC-CHILDHOOD-LEUKEMIA-COOPERATIVE-GROUP [J].

FERSTER, A ;

BERTRAND, Y ;

BENOIT, Y ;

BOILLETOT, A ;

BEHAR, C ;

MARGUERITTE, G ;

THYSS, A ;

ROBERT, A ;

MAZINGUE, F ;

SOUILLET, G ;

PHILIPPE, N ;

SOLBU, G ;

SUCIU, S ;

OTTEN, J .

BRITISH JOURNAL OF HAEMATOLOGY, 1994, 86 (02) :284-290

[6]

Greaves MF, 1996, LEUKEMIA, V10, P372

[7]

Hicsonmez G, 1982, Turk J Pediatr, V24, P159

[8]

Hicsonmez G, 1997, EUR J HAEMATOL, V58, P26

[9] Long-term results of Total Therapy studies 11, 12 and 13A for childhood acute lymphoblastic leukemia at St Jude Children's Research Hospital [J].

Pui, CH ;

Boyett, JM ;

Rivera, GK ;

Hancock, ML ;

Sandlund, JT ;

Ribeiro, RC ;

Rubnitz, JE ;

Behm, FG ;

Raimondi, SC ;

Gajjar, A ;

Razzouk, B ;

Campana, D ;

Kun, LE ;

Relling, MV ;

Evans, WE .

LEUKEMIA, 2000, 14 (12) :2286-2294

[10]

Pui CH, 1996, LEUKEMIA, V10, P952

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