Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1

被引：15

作者：

Gopalsamy, A

Kincaid, SL

Ellingboe, JW

Groeling, TM

Antrilli, TM

Krishnamurthy, G

Aulabaugh, A

Friedrichs, GS

Crandall, DL

机构：

[1] Wyeth Ayerst Res, Chem & Screening Sci, Pearl River, NY 10965 USA

[2] Wyeth Ayerst Res, Cardiovasc & Metab Dis Res, Collegeville, PA 19426 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 13期

关键词：

PAI-1; inhibitor; oxadiazolidine diones; parallel synthesis;

D O I：

10.1016/j.bmcl.2004.04.058

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of PAI-1 inhibitors containing an oxadiazolidinedione moiety were identified by high through-put screening. Optimization of substituents by parallel synthesis and the iterative design toward understanding structure-activity relationship to improve potency are described. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：3477 / 3480

页数：4

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