Synthesis, Characterization and Antibacterial Activity of Novel Coumarin

被引：1

作者：

Zhang, Tian-Lin ^{[1
]}

Ma, Hui-Min ^{[1
,2
]}

Zhu, Cai-Yan ^{[1
,2
]}

Wang, Jia-Jia ^{[1
,2
]}

Wang, Bing-Bing ^{[3
]}

机构：

[1] Huaihai Inst Technol, Dept Chem Engn, Lianyungang 222005, Peoples R China

[2] China Univ Min & Technol, Sch Chem Engn & Technol, Xuzhou 221116, Peoples R China

[3] China Univ Min & Technol, Coll Environm & Spatial Informat, Xuzhou 221116, Peoples R China

来源：

ASIAN JOURNAL OF CHEMISTRY | 2013年 / 25卷 / 18期

关键词：

Coumrin; 5-Chloromethylsalicylaldehyde; Quaternary ammonium salt; Antibacterial activity;

D O I：

10.14233/ajchem.2013.15197

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The novel coumarin derivative based quaternary ammonium salt had been designed and synthesized in two steps starting from 5-chloromethylsalicylaldehyde. 5-Chloromethylsalicylaldehyde first reacted with tertiary amine to yield the quaternary ammonium salt, then this compound reacted with the diethyl malonate on the appropriate condition to yield the corresponding coumarin derivative. The chemical structure had been elucidated by infrared spectra, H-1 NMR spectra, LC-MS and melting point analysis. The novel coumarin had been evaluated for its antibacterial activities in vitro against foru gram-negative bacteria (Edwardsiella tarda, Aeromonas hydrophila, Vibrio anguillarum and Vibrio harveyi). The bioactive assay showed that the title compound displayed comparable antibacterial efficacy in comparison with some of other reference drugs.

引用

页码：10144 / 10146

页数：3

共 21 条

[1]

Alaa S.A., 2007, J HETEROCYCLIC CHEM, V44, P1287

[2]

Alexandra M.B., 2012, PROGR POLYM SCI, V37, P281

[3] BSAC standardized disc susceptibility testing method (vol 48, S1, pg 43, 2001) [J].

Andrews, JM .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2002, 49 (06) :1049-1049

[4] Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives [J].

Arshad, Afsheen ;

Osman, Hasnah ;

Bagley, Mark C. ;

Lam, Chan Kit ;

Mohamad, Suriyati ;

Zahariluddin, Anis Safirah Mohd .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (09) :3788-3794

[5]

Bernadette S.C., 2007, J INORG BIOCHEM, V101, P1108

[6]

BERNADETTE SC, 2006, INORG CHIM ACTA, V359, P3976

[7]

Geoffrey L., 1994, [No title captured], Patent No. [US005286803A, 005286803A]

[8]

Harold A.G., 1984, [No title captured], Patent No. [US44790, 44790]

[9]

Joanna T.K., 2010, EUR J MED CHEM, V46, P2252

[10] Biological evaluation of coumarin derivatives as mushroom tyrosinase inhibitors [J].

Liu, Jinbing ;

Wu, Fengyan ;

Chen, Lingjuan ;

Zhao, Liangzhong ;

Zhao, Zibing ;

Wang, Min ;

Lei, Sulan .

FOOD CHEMISTRY, 2012, 135 (04) :2872-2878

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