FILGOTINIB, A SELECTIVE JANUS KINASE 1 (JAK1) INHIBITOR, MODULATES DISEASE-ASSOCIATED CYTOKINES IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS

被引：0
|
作者：
Taylor, Peter C. [1 ]
Elboudwarej, Emon [2 ]
LI Wanying [2 ]
Hawtin, Rachael E. [2 ]
Liu, Jinfeng [2 ]
Mirza, Amer M. [2 ]
机构：
[1] Univ Oxford, Botnar Res Ctr, Oxford, England
[2] Gilead Sci Inc, 353 Lakeside Dr, Foster City, CA 94404 USA
来源：
ANNALS OF THE RHEUMATIC DISEASES | 2019年 / 78卷
关键词：
D O I：
10.1136/annrheumdis-2019-eular.2510
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
FRI0133
引用
收藏
页码：736 / 736
页数：1
相关论文
共 50 条
  • [1] SELECTIVE INHIBITION OF JANUS KINASE 1 (JAK1) BY FILGOTINIB MODULATES THE DISEASE-ASSOCIATED WHOLE BLOOD TRANSCRIPTIONAL PROFILE OF PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS
    Taylor, Peter C.
    Downie, Bryan
    Zhuo, Luting
    Hawtin, Rachael E.
    Liu, Jinfeng
    Mirza, Amer M.
    ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 : 374 - 375
  • [2] FILGOTINIB, A JANUS KINASE 1 SELECTIVE INHIBITOR, MODULATES DISEASE-ASSOCIATED CYTOKINES IN PATIENTS WITH ACTIVE RA
    Taylor, Peter C.
    Elboudwarej, Emon
    Li, Wanying
    Hawtin, Rachael E.
    Liu, Jinfeng
    Mirza, Amer M.
    RHEUMATOLOGY, 2020, 59
  • [3] THE JAK1-SELECTIVE INHIBITOR FILGOTINIB REVERSES THE DISEASE-ASSOCIATED TRANSCRIPTIONAL PROFILE IN THE BLOOD OF PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS
    Taylor, Peter
    Downie, Bryan
    Zhuo, Luting
    Gindin, Yevgeniy
    Tarrant, Jacqueline
    Galien, Rene
    Liu, Jinfeng
    Mirza, Amer M.
    RHEUMATOLOGY, 2019, 58 : 24 - 24
  • [4] The JAK1-Selective Inhibitor Filgotinib Reverses the Disease-Associated Transcriptional Profile Found in the Blood of Patients with Active Rheumatoid Arthritis
    Taylor, Peter C.
    Downie, Bryan
    Zhuo, Luting
    Gindin, Yevgeniy
    Tarrant, Jacqueline
    Liu, Jinfeng
    Galien, Rene
    Mirza, Amer M.
    ARTHRITIS & RHEUMATOLOGY, 2018, 70
  • [5] Effects of the Janus Kinase 1 (JAK1)-selective inhibitor filgotinib on circulating cytokines and whole-blood genes/pathways of patients with moderately to severely active Crohn's disease (CD)
    Roblin, X.
    Serone, A.
    Yoon, O. K.
    Zhuo, L.
    Grant, E.
    Woo, J.
    Liu, J.
    Galien, R.
    D'Haens, G.
    JOURNAL OF CROHNS & COLITIS, 2020, 14 : S457 - S458
  • [6] Filgotinib, a JAK1 Inhibitor, for Treatment-Resistant Rheumatoid Arthritis
    Singh, Jasvinder A.
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2019, 322 (04): : 309 - 311
  • [7] EFFECTS OF THE JANUS KINASE (JAK1)-SELECTIVE INHIBITOR FILGOTINIB (FIL) ON CIRCULATING CYTOKINES AND WHOLE-BLOOD GENES/PATHWAYS OF PATIENTS WITH MODERATELY TO SEVERELY ACTIVE CROHN'S DISEASE (CD)
    Roblin, Xavier
    Serone, Adrian
    Yoon, Oh Kyu
    Zhuo, Luting
    Grant, Ethan
    Woo, Jacky
    Liu, James
    Galien, Rene
    D'Haens, Geert R.
    GASTROENTEROLOGY, 2020, 158 (06) : S1201 - S1202
  • [8] Peripheral Protein Biomarker Changes Following Selective Inhibition of Janus Kinase 1 (JAK1) by Filgotinib in Methotrexate Naive Adults with Moderately-to-Severely Active Rheumatoid Arthritis
    Taylor, Peter
    Mirza, Amer
    Downie, Bryan
    Liu, Jinfeng
    Hawtin, Rachael
    Elboudwarej, Emon
    ARTHRITIS & RHEUMATOLOGY, 2020, 72
  • [9] EFFECTS OF THE JAK1-SELECTIVE INHIBITOR FILGOTINIB ON GENE EXPRESSION PROFILE IN BLOOD OF PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS
    Taylor, P. C.
    Tarrant, J.
    Zhao, L.
    Gindin, Y.
    Mirza, A.
    Harrison, P.
    Tasset, C.
    Galien, R.
    Van der Aa, A.
    Downie, B.
    ANNALS OF THE RHEUMATIC DISEASES, 2018, 77 : 976 - 977
  • [10] Whole Blood Transcriptional Changes Following Selective Inhibition of Janus Kinase 1 (JAK1) by Filgotinib in MTX-Naive Adults with Moderately-to-Severely Active Rheumatoid Arthritis (RA)
    Taylor, Peter
    Downie, Bryan
    Elboudwarej, Emon
    Kim, Sam
    Hertz, Angie
    Mirza, Amer
    Siegel, Jeff
    Hawtin, Rachael
    Liu, Jinfeng
    ARTHRITIS & RHEUMATOLOGY, 2020, 72
12345