In situ assessment of atorvastatin impurity using MALDI mass spectrometry imaging (MALDI-MSI)

被引：17
作者：
Rodrigues, Livia Riberti [1 ]
de Oliveira, Diogo Noin [1 ]
Ferreira, Monica Siqueira [1 ]
Catharino, Rodrigo Ramos [1 ]
机构：
[1] Univ Estadual Campinas, Sch Med Sci, Med & Expt Surg Dept, INNOVARE Biomarkers Lab, BR-13083877 Campinas, SP, Brazil
来源：
ANALYTICA CHIMICA ACTA | 2014年 / 818卷
基金：
巴西圣保罗研究基金会;
关键词：
Atorvastatin; Impurities; Quality control; Mass spectrometry imaging; DEGRADATION-PRODUCTS; STRESS DEGRADATION; TOF-MS; LOCALIZATION; QUANTITATION; STATIN; DRUGS; LC;
D O I：
10.1016/j.aca.2014.01.050
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The analysis of impurities and degradation products in pharmaceutical preparations are usually performed by chromatographic techniques such as high-performance liquid chromatography (HPLC). This approach demands extensive analysis time, mostly due to extraction and separation phases. These steps must be carried out in samples in order to adapt them to the requirements of the analytical method of choice. In the present contribution, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was employed to quantify an important degradation product in atorvastatin calcium 80 mg tablets: the atorvastatin lactone. Through the standard of the impurity, it was possible to perform quantitative analysis directly on the drug tablet, using a quick and novel approach, suitable for quality control processes in the pharmaceutical industry. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：32 / 38
页数：7
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