Efficacy of Antivascular Photodynamic Therapy Using Benzoporphyrin Derivative Monoacid Ring A (BPD-MA) in 14 Dogs with Oral and Nasal Tumors

被引:17
作者
Osaki, Tomohiro [1 ]
Takagi, Satoshi [1 ]
Hoshino, Yuki [1 ]
Okumura, Masahiro [1 ]
Kadosawa, Tsuyoshi [1 ]
Fujinaga, Toru [1 ]
机构
[1] Hokkaido Univ, Grad Sch Vet Med, Dept Vet Clin Sci, Lab Vet Surg,Kita Ku, Sapporo, Hokkaido 0600818, Japan
关键词
BPD-MA; nasal tumor; oral tumor; photodynamic therapy; CLINICAL PHARMACOKINETICS; RADIOTHERAPY; CANCER; ENHANCEMENT; IRRADIATION; NEOPLASMS; CARCINOMA; RESECTION;
D O I
10.1292/jvms.71.125
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Antivascular photodynamic therapy (PDT) Suppresses tumor growth and prolonged the survival in solid tumor-bearing mice. The purpose of this study was to assess the efficacy of antivascular PDT using BPD-MA for treatment of oral and nasal tumors in 14 dogs. At 15 min after initiating intravenous infusion of 0.5 mg/kg benzoporphyrin derivative monoacid ring A, tumors were irradiated with laser light at 690 nm emitted by a diode laser, The 1-year survival rate of 7 dogs with oral tumors was 71%. The 1-year Survival rate of 7 does with nasal tumors was 57%. Imaging of each tumor was performed by using angiographic computed tomography before and after each antivascular PDT. Contrast-enhanced turners were observed before antivascular PDT, but these tumors were not enhanced with contrast medium following antivascular PDT. Antivascular PDT is suggested to be a promising method for dogs with oral and nasal tumors that cannot be effectively treated with current antitumor therapies.
引用
收藏
页码:125 / 132
页数:8
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