Bioactive Cembranoids from the Soft Coral Genus Sinularia sp in Borneo

被引：35

作者：

Kamada, Takashi ^{[1
]}

Kang, Min-Cheol ^{[2
]}

Phan, Chin-Soon ^{[1
]}

Zanil, Intan Irna ^{[1
]}

Jeon, You-Jin ^{[2
]}

Vairappan, Charles S. ^{[1
]}

机构：

[1] Univ Malaysia Sabah, Inst Trop Biol & Conservat, Lab Nat Prod Chem, Kota Kinabalu 88400, Sabah, Malaysia

[2] Jeju Natl Univ, Dept Marine Life Sci, Jeju 690756, South Korea

来源：

MARINE DRUGS | 2018年 / 16卷 / 04期

关键词：

cembrane; terpenoid; soft coral; Sinularia; anti-inflammation; apoptosis; structure-activity relationship; NEPHTHEA SP; SARCOPHYTON-CRASSOCAULE; LOBOPHYTUM-CRASSUM; CAPNELLA SP; DITERPENES; CAPGERMACRENES; TERPENOIDS; FLEXIBILIS; APOPTOSIS; CELLS;

D O I：

10.3390/md16040099

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F (2), along with three known compounds, cembranolide (1), (E,E,E)-6,10,14-trimethyl-3-methylene-cis-3 alpha,4,5,8,9,12,13,15 alpha-octahydrocyclo tetradeca[beta]furan-2(3H)-one(3), and denticulatolide (4), were isolated from the Bornean soft coral Sinularia sp. Compounds 2 and 4 showed potential anti-inflammatory activities against lipopolysaccharide-stimulated RAW 264.7 with IC50 values less than 6.25 mu g/mL and anticancer activity against HL60 cell lines. The compounds' mechanisms of action were investigated via the Western blot evaluation of their protein markers. These activities could be attributed to the presence of tertiary methyl at C-8 and the compounds' 3D configurations.

引用

页数：14

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