Role of plants in anticancer drug discovery

被引：120
作者：
Khazir, Jabeena [1 ]
Mir, Bilal Ahmad [2 ]
Pilcher, Lynne [1 ]
Riley, Darren L. [1 ]
机构：
[1] Univ Pretoria, Dept Chem, ZA-0028 Pretoria, South Africa
[2] Univ Pretoria, Dept Genet, Ctr Microbial Ecol & Genom, ZA-0028 Pretoria, South Africa
来源：
PHYTOCHEMISTRY LETTERS | 2014年 / 7卷
关键词：
Cancer; Drugs; Natural products; Plant derived anticancer drugs; EVERY; 3; WEEKS; PHASE-I; BETULINIC ACID; NATURAL-PRODUCTS; CANCER CHEMOPREVENTION; INTRAVENOUS-INFUSION; CLINICAL-EXPERIENCE; INDUCED APOPTOSIS; PERILLYL ALCOHOL; STRUCTURAL BASIS;
D O I：
10.1016/j.phytol.2013.11.010
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Cancer is one of the major causes of death and the number of new cases, as well as the number of individuals living with cancer, is expanding continuously. Worldwide the alarming rise in mortality rate due to cancer has fuelled the pursuit for effective anticancer agents to combat this disease. Finding novel and efficient compounds of natural origin has been a major point of concern for research in the pharmaceutical sciences. Plants have been seen to possess the potential to be excellent lead structures and to serve as a basis of promising therapeutic agents for cancer treatment. Many successful anti-cancer drugs currently in use or their analogues are plant derived and many more are under clinical trials. This review aims to highlight the invaluable role that plants have played, and continue to play, in the discovery of anticancer agents. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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收藏
页码：173 / 181
页数：9
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