Epigenetics of β-globin gene regulation

被引：52

作者：

Kiefer, Christine M. ^{[1
]}

Hou, Chunhui ^{[1
]}

Little, Jane A. ^{[2
]}

Dean, Ann ^{[1
]}

机构：

[1] NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA

[2] Albert Einstein Coll Med, Dept Med, Div Hematol, Bronx, NY 10461 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2008年 / 647卷 / 1-2期

关键词：

beta-Globin; Chromatin; Epigenetics; Histone modifications; Locus control regions; Insulators;

D O I：

10.1016/j.mrfmmm.2008.07.014

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

It is widely recognized that the next great challenge in the post-genomic period is to understand how the genome establishes the cell and tissue specific patterns of gene expression that underlie development. The P-globin genes are among the most extensively studied tissue specific and developmentally regulated genes. The onset of erythropoiesis in precursor cells and the progressive expression of different members of the P-globin family during development are accompanied by dramatic epigenetic changes in the locus. In this review, we will consider the relationship between histone and DNA modifications and the transcriptional activity of the P-globin genes, the dynamic changes in epigenetic modifications observed during erythroid development, and the potential these changes hold as new targets for therapy in human disease. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：68 / 76

页数：9

共 97 条

[1] Intergenic transcription and transinduction of the human beta-globin locus [J].

Ashe, HL ;

Monks, J ;

Wijgerde, M ;

Fraser, P ;

Proudfoot, NJ .

GENES & DEVELOPMENT, 1997, 11 (19) :2494-2509

[2]

Atweh GF, 1999, BLOOD, V93, P1790

[3] The protein CTCF is required for the enhancer blocking activity of vertebrate insulators [J].

Bell, AC ;

West, AG ;

Felsenfeld, G .

CELL, 1999, 98 (03) :387-396

[4] Flanking HS-62.5 and 3′ HS1, and regions upstream of the LCR, are not required for β-globin transcription [J].

Bender, M. A. ;

Byron, Rachel ;

Ragoczy, Tobias ;

Telling, Agnes ;

Bulger, Michael ;

Groudine, Mark .

BLOOD, 2006, 108 (04) :1395-1401

[5] Description and targeted deletion of 5′ hypersensitive site 5 and 6 of the mouse β-globin locus control region [J].

Bender, MA ;

Reik, A ;

Close, J ;

Telling, A ;

Epner, E ;

Fiering, S ;

Hardison, R ;

Groudine, M .

BLOOD, 1998, 92 (11) :4394-4403

[6] β-globin gene switching and DNase I sensitivity of the endogenous β-globin locus in mice do not require the locus control region [J].

Bender, MA ;

Bulger, M ;

Close, J ;

Groudine, M .

MOLECULAR CELL, 2000, 5 (02) :387-393

[7] The complex language of chromatin regulation during transcription [J].

Berger, Shelley L. .

NATURE, 2007, 447 (7143) :407-412

[8] Developmental stage-specific epigenetic control of human β-globin gene expression is potentiated in hematopoietic progenitor cells prior to their transcriptional activation [J].

Bottardi, S ;

Aumont, A ;

Grosveld, F ;

Milot, E .

BLOOD, 2003, 102 (12) :3989-3997

[9] Conservation of sequence and structure flanking the mouse and human β-globin loci:: The β-globin genes are embedded within an array of odorant receptor genes [J].

Bulger, M ;

von Doorninck, JH ;

Saitoh, N ;

Telling, A ;

Farrell, C ;

Bender, MA ;

Felsenfeld, G ;

Axel, R ;

Groudine, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (09) :5129-5134

[10] A complex chromatin landscape revealed by patterns of nuclease sensitivity and histone modification within the mouse β-globin locus [J].

Bulger, M ;

Schübeler, D ;

Bender, MA ;

Hamilton, J ;

Farrell, CM ;

Hardison, RC ;

Groudine, M .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (15) :5234-5244

← 1 2 3 4 5 6 7 8 9 10 →