Chromatography in the Detection and Characterization of Illegal Pharmaceutical Preparations

被引：57

作者：

Deconinck, Eric ^{[1
]}

Sacre, Pierre-Yves ^{[1
,2
]}

Courselle, Patricia ^{[1
]}

De Beer, Jacques O. ^{[1
]}

机构：

[1] Sci Inst Publ Hlth WIV ISP, Sect Med Prod, Div Food Med & Consumer Safety, B-1050 Brussels, Belgium

[2] Univ Liege, CIRM, Analyt Chem Lab, B-4000 Liege, Belgium

来源：

JOURNAL OF CHROMATOGRAPHIC SCIENCE | 2013年 / 51卷 / 08期

关键词：

PERFORMANCE LIQUID-CHROMATOGRAPHY; THIN-LAYER-CHROMATOGRAPHY; PRESSURE GAS-CHROMATOGRAPHY; IONIZATION MASS-SPECTROMETRY; SYNTHETIC PHOSPHODIESTERASE-5 INHIBITORS; ARTESUNATE ANTIMALARIAL TABLETS; QUALITY CONSISTENCY EVALUATION; ERECTILE DYSFUNCTION DRUGS; TEA ANTIOXIDANT CAPACITY; LC-ESI-MS;

D O I：

10.1093/chromsci/bmt006

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Counterfeit and illegal pharmaceutical products are an increasing worldwide problem and constitute a major challenge for analytical laboratories to detect and characterize them. Spectroscopic techniques such as infrared spectroscopy and Raman spectroscopy have always been the first methods of choice to detect counterfeits and illegal preparations, but due to the evolution in the seized products and the necessity of risk assessment, chromatographic methods are becoming more important in this domain. This review intends to give a general overview of the techniques described in literature to characterize counterfeit and illegal pharmaceutical preparations, focusing on the role of chromatographic techniques with different detection tools.

引用

页码：791 / 806

页数：16

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