Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity

被引：432

作者：

Bardina, Susana V. ^{[1
]}

Bunduc, Paul ^{[1
]}

Tripathi, Shashank ^{[1
,2
]}

Duehr, James ^{[1
]}

Frere, Justin J. ^{[1
]}

Brown, Julia A. ^{[1
]}

Nachbagauer, Raffael ^{[1
]}

Foster, Gregory A. ^{[3
]}

Krysztof, David ^{[3
]}

Tortorella, Domenico ^{[1
]}

Stramer, Susan L.

Garcia-Sastre, Adolfo ^{[1
,2
,4
]}

Krammer, Florian ^{[1
]}

Lim, Jean K. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Global Hlth & Emerging Pathogens Inst, New York, NY 10029 USA

[3] Amer Red Cross, Gaithersburg, MD 20877 USA

[4] Icahn Sch Med Mt Sinai, Div Infect Dis, Dept Med, New York, NY 10029 USA

来源：

SCIENCE | 2017年 / 356卷 / 6334期

关键词：

WEST-NILE-VIRUS; ANTIBODY-DEPENDENT ENHANCEMENT; DENGUE HEMORRHAGIC-FEVER; CROSS-REACTIVITY; INFECTION; FC; FLAVIVIRUSES; EPIDEMIOLOGY; ACTIVATION; CORRELATE;

D O I：

10.1126/science.aal4365

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Zika virus (ZIKV) is spreading rapidly into regions around the world where other flaviviruses, such as dengue virus (DENV) and West Nile virus (WNV), are endemic. Antibody-dependent enhancement has been implicated in more severe forms of flavivirus disease, but whether this also applies to ZIKV infection is unclear. Using convalescent plasma from DENV- and WNV-infected individuals, we found substantial enhancement of ZIKV infection in vitro that was mediated through immunoglobulin G engagement of Fcg receptors. Administration of DENV- or WNV-convalescent plasma into ZIKV-susceptible mice resulted in increased morbidity-including fever, viremia, and viral loads in spinal cord and testes-and increased mortality. Antibody-dependent enhancement may explain the severe disease manifestations associated with recent ZIKV outbreaks and highlights the need to exert great caution when designing flavivirus vaccines.

引用

页码：175 / 180

页数：6

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