Facile construction of trifluoromethyl-azirines via one-pot metal-free Neber reaction

被引：10

作者：

Huang, Yin-Jun ^{[1
,2
]}

Qiao, Baokun ^{[1
,2
]}

Zhang, Fa-Guang ^{[1
,2
]}

Ma, Jun-An ^{[1
,2
]}

机构：

[1] Tianjin Univ, Tianjin Key Lab Mol Optoelect Sci, Dept Chem, Tianjin 300072, Peoples R China

[2] Tianjin Univ, Tianjin Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China

来源：

TETRAHEDRON | 2018年 / 74卷 / 28期

基金：

中国国家自然科学基金;

关键词：

Neber; Trifluoromethyl; Azirine; Ketoxime; One-pot reaction; ENANTIOMERICALLY ENRICHED 2H-AZIRINES; GOLD-CATALYZED SYNTHESIS; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; PHOTOREDOX CATALYSIS; PYRROLE SYNTHESIS; BOND-CLEAVAGE; ESTERS; COPPER; ISOMERIZATION;

D O I：

10.1016/j.tet.2018.05.033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Et3N-mediated Neber reaction of aryl/alkyl-2,2,2-trifluoroethylketoximes has been developed. This one-pot metal-free protocol enables the facile construction of an array of trifluoromethyl-substituted azirines in moderate to high yields under mild reaction conditions. Further transformations of azirines to CF3-containing pyrrole and amino-alcohol derivatives are also demonstrated. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：3791 / 3796

页数：6

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