Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia

被引：109
作者：
Rubins, JB
Pomeroy, C
机构：
[1] VET ADM MED CTR,DIV INFECT DIS,MINNEAPOLIS,MN 55417
[2] UNIV MINNESOTA,DEPT MED,MINNEAPOLIS,MN 55455
来源：
INFECTION AND IMMUNITY | 1997年 / 65卷 / 07期
关键词：
D O I：
10.1128/IAI.65.7.2975-2977.1997
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Gamma interferon (IFN-gamma) concentrations in blood, but not in lungs, rose significantly at 24 to 48 h after murine pulmonary infection with virulent pneumococci. In contrast, infection with avirulent pneumococcal strains produced minimal rises in serum IFN-gamma concentrations. Compared with that of immunocompetent mice, mortality was appreciably increased after pulmonary infection of IFN-gamma gene knockout mice, suggesting a protective role for IFN-gamma in host response to pneumococcal disease.
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收藏
页码：2975 / 2977
页数：3
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