DNA methylation signatures of mood stabilizers and antipsychotics in bipolar disorder

被引：61

作者：

Houtepen, Lotte C. ^{[1
]}

van Bergen, Annet H. ^{[1
]}

Vinkers, Christiaan H. ^{[1
]}

Boks, Marco P. M. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Psychiat, Utrecht, Netherlands

来源：

EPIGENOMICS | 2016年 / 8卷 / 02期

关键词：

antidepressant; antipsychotics; bipolar; cell type; DNA methylation; medication; mood stabilizer; HISTONE DEACETYLASE INHIBITORS; VALPROIC ACID; GENE-EXPRESSION; MICROGLIAL ACTIVATION; EPIGENETIC MECHANISMS; SCHIZOPHRENIA; QUETIAPINE; NEURONS; BRAIN; DEMETHYLATION;

D O I：

10.2217/epi.15.98

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: In view of the potential effects of psychiatric drugs on DNA methylation, we investigated whether medication use in bipolar disorder is associated with DNA methylation signatures. Experimental procedures: Blood-based DNA methylation patterns of six frequently used psychotropic drugs (lithium, quetiapine, olanzapine, lamotrigine, carbamazepine, and valproic acid) were examined in 172 bipolar disorder patients. After adjustment for cell type composition, we investigated gene networks, principal components, hypothesis-driven genes and epigenome-wide individual loci. Results: Valproic acid and quetiapine were significantly associated with altered methylation signatures after adjustment for drug-related changes on celltype composition. Conclusion: Psychiatric drugs influence DNA methylation patterns over and above cell type composition in bipolar disorder. Drug-related changes in DNA methylation are therefore not only an important confounder in psychiatric epigenetics but may also inform on the biological mechanisms underlying drug efficacy.

引用

页码：197 / 208

页数：12

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